Constitutive signal bias mediated by the human GHRHR splice variant 1

Alternative splicing of G protein–coupled receptors has been observed, but their functions are largely unknown. Here, we report that a splice variant (SV1) of the human growth hormone–releasing hormone receptor (GHRHR) is capable of transducing biased signal. Differing only at the receptor N terminu...

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Detalles Bibliográficos
Autores principales: Cong, Zhaotong, Zhou, Fulai, Zhang, Chao, Zou, Xinyu, Zhang, Huibing, Wang, Yuzhe, Zhou, Qingtong, Cai, Xiaoqing, Liu, Qiaofeng, Li, Jie, Shao, Lijun, Mao, Chunyou, Wang, Xi, Wu, Jihong, Xia, Tian, Zhao, Li-Hua, Jiang, Hualiang, Zhang, Yan, Xu, H. Eric, Cheng, Xi, Yang, Dehua, Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501799/
https://www.ncbi.nlm.nih.gov/pubmed/34599099
http://dx.doi.org/10.1073/pnas.2106606118

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