Computational modeling identifies multitargeted kinase inhibitors as effective therapies for metastatic, castration-resistant prostate cancer

Castration-resistant prostate cancer (CRPC) is an advanced subtype of prostate cancer with limited therapeutic options. Here, we applied a systems-based modeling approach called kinome regularization (KiR) to identify multitargeted kinase inhibitors (KIs) that abrogate CRPC growth. Two predicted KIs...

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Detalles Bibliográficos
Autores principales: Bello, Thomas, Paindelli, Claudia, Diaz-Gomez, Luis A., Melchiorri, Anthony, Mikos, Antonios G., Nelson, Peter S., Dondossola, Eleonora, Gujral, Taranjit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501846/
https://www.ncbi.nlm.nih.gov/pubmed/34593636
http://dx.doi.org/10.1073/pnas.2103623118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501846/
https://www.ncbi.nlm.nih.gov/pubmed/34593636
http://dx.doi.org/10.1073/pnas.2103623118

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