Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs

Approximately 40% of human messenger RNAs (mRNAs) contain upstream open reading frames (uORFs) in their 5′ untranslated regions. Some of these uORF sequences, thought to attenuate scanning ribosomes or lead to mRNA degradation, were recently shown to be translated, although the function of the encod...

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Detalles Bibliográficos
Autores principales: Jayaram, Divya Ram, Frost, Sigal, Argov, Chanan, Liju, Vijayasteltar Belsamma, Anto, Nikhil Ponnoor, Muraleedharan, Amitha, Ben-Ari, Assaf, Sinay, Rose, Smoly, Ilan, Novoplansky, Ofra, Isakov, Noah, Toiber, Debra, Keasar, Chen, Elkabets, Moshe, Yeger-Lotem, Esti, Livneh, Etta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501901/
https://www.ncbi.nlm.nih.gov/pubmed/34593629
http://dx.doi.org/10.1073/pnas.2018899118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501901/
https://www.ncbi.nlm.nih.gov/pubmed/34593629
http://dx.doi.org/10.1073/pnas.2018899118

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