Designed architectural proteins that tune DNA looping in bacteria

Architectural proteins alter the shape of DNA. Some distort the double helix by introducing sharp kinks. This can serve to relieve strain in tightly-bent DNA structures. Here, we design and test artificial architectural proteins based on a sequence-specific Transcription Activator-like Effector (TAL...

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Detalles Bibliográficos
Autores principales: Tse, David H, Becker, Nicole A, Young, Robert T, Olson, Wilma K, Peters, Justin P, Schwab, Tanya L, Clark, Karl J, Maher, L James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501960/
https://www.ncbi.nlm.nih.gov/pubmed/34478548
http://dx.doi.org/10.1093/nar/gkab759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501960/
https://www.ncbi.nlm.nih.gov/pubmed/34478548
http://dx.doi.org/10.1093/nar/gkab759

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