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Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men

PURPOSE: Symptoms of hypogonadism are often reported by subjects with normal serum testosterone (T) levels. We aimed to assess the association between clinical symptoms in andrological outpatients and sex steroids levels. METHODS: This is a retrospective cross-sectional cohort study in an Academic c...

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Autores principales: Sansone, A., Kliesch, S., Dugas, M., Sandhowe-Klaverkamp, R., Isidori, A. M., Schlatt, S., Zitzmann, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502125/
https://www.ncbi.nlm.nih.gov/pubmed/33811609
http://dx.doi.org/10.1007/s40618-021-01561-0
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author Sansone, A.
Kliesch, S.
Dugas, M.
Sandhowe-Klaverkamp, R.
Isidori, A. M.
Schlatt, S.
Zitzmann, M.
author_facet Sansone, A.
Kliesch, S.
Dugas, M.
Sandhowe-Klaverkamp, R.
Isidori, A. M.
Schlatt, S.
Zitzmann, M.
author_sort Sansone, A.
collection PubMed
description PURPOSE: Symptoms of hypogonadism are often reported by subjects with normal serum testosterone (T) levels. We aimed to assess the association between clinical symptoms in andrological outpatients and sex steroids levels. METHODS: This is a retrospective cross-sectional cohort study in an Academic clinic and research unit. International Index of Erectile Function (IIEF, EF domain) and Aging Males Symptoms scale (AMS) questionnaires were completed by 635 and 574 men, respectively (mean age: 47.3 ± 13.9 and 47.4 ± 13.8 years, p = 0.829), free of interfering medications with complaints possibly related to hypogonadism. RESULTS: Serum total/free T as well as dihydro-T (DHT) was associated with IIEF-EF and AMS scores in the overall population using univariate analyses. Multivariate approaches revealed DHT concentrations in subjects with normal T levels (n = 416, Total T > 12 nmol/L) to be significant predictors of AMS scores. A 0.1 nmol/l serum DHT increase within the eugonadal range was associated with a 4.67% decrease in odds of having worse symptoms (p = 0.011). In men with biochemical hypogonadism (Total T < 12 nmol/L), total and free T rather than DHT were associated with AMS results. This association was not found for IIEF-EF scores. Indirect effects of age and BMI were seen for relations with hormone concentrations but not questionnaire scores. CONCLUSION: DHT can be associated with symptoms of hypogonadism in biochemically eugonadal men. Serum DHT measurement might be helpful once the diagnosis of hypogonadism has been ruled out but should not be routinely included in the primary diagnostic process. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-021-01561-0.
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spelling pubmed-85021252021-10-22 Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men Sansone, A. Kliesch, S. Dugas, M. Sandhowe-Klaverkamp, R. Isidori, A. M. Schlatt, S. Zitzmann, M. J Endocrinol Invest Original Article PURPOSE: Symptoms of hypogonadism are often reported by subjects with normal serum testosterone (T) levels. We aimed to assess the association between clinical symptoms in andrological outpatients and sex steroids levels. METHODS: This is a retrospective cross-sectional cohort study in an Academic clinic and research unit. International Index of Erectile Function (IIEF, EF domain) and Aging Males Symptoms scale (AMS) questionnaires were completed by 635 and 574 men, respectively (mean age: 47.3 ± 13.9 and 47.4 ± 13.8 years, p = 0.829), free of interfering medications with complaints possibly related to hypogonadism. RESULTS: Serum total/free T as well as dihydro-T (DHT) was associated with IIEF-EF and AMS scores in the overall population using univariate analyses. Multivariate approaches revealed DHT concentrations in subjects with normal T levels (n = 416, Total T > 12 nmol/L) to be significant predictors of AMS scores. A 0.1 nmol/l serum DHT increase within the eugonadal range was associated with a 4.67% decrease in odds of having worse symptoms (p = 0.011). In men with biochemical hypogonadism (Total T < 12 nmol/L), total and free T rather than DHT were associated with AMS results. This association was not found for IIEF-EF scores. Indirect effects of age and BMI were seen for relations with hormone concentrations but not questionnaire scores. CONCLUSION: DHT can be associated with symptoms of hypogonadism in biochemically eugonadal men. Serum DHT measurement might be helpful once the diagnosis of hypogonadism has been ruled out but should not be routinely included in the primary diagnostic process. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-021-01561-0. Springer International Publishing 2021-04-03 2021 /pmc/articles/PMC8502125/ /pubmed/33811609 http://dx.doi.org/10.1007/s40618-021-01561-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Sansone, A.
Kliesch, S.
Dugas, M.
Sandhowe-Klaverkamp, R.
Isidori, A. M.
Schlatt, S.
Zitzmann, M.
Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
title Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
title_full Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
title_fullStr Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
title_full_unstemmed Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
title_short Serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
title_sort serum concentrations of dihydrotestosterone are associated with symptoms of hypogonadism in biochemically eugonadal men
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502125/
https://www.ncbi.nlm.nih.gov/pubmed/33811609
http://dx.doi.org/10.1007/s40618-021-01561-0
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