Cargando…
Shortened leukocyte telomere length in young adults who use methamphetamine
Methamphetamine (METH) use, most prevalent in young adults, has been associated with high rates of morbidity and mortality. The relationship between METH use and accelerated biological aging, which can be measured using leukocyte telomere length (LTL), remains unclear. We examined whether young adul...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502172/ https://www.ncbi.nlm.nih.gov/pubmed/34628468 http://dx.doi.org/10.1038/s41398-021-01640-z |
_version_ | 1784580835291168768 |
---|---|
author | Lin, Yen-Feng Chen, Po-Yu Liu, Hsing-Cheng Chen, Yi-Lung Chou, Wei-Hern Huang, Ming-Chyi |
author_facet | Lin, Yen-Feng Chen, Po-Yu Liu, Hsing-Cheng Chen, Yi-Lung Chou, Wei-Hern Huang, Ming-Chyi |
author_sort | Lin, Yen-Feng |
collection | PubMed |
description | Methamphetamine (METH) use, most prevalent in young adults, has been associated with high rates of morbidity and mortality. The relationship between METH use and accelerated biological aging, which can be measured using leukocyte telomere length (LTL), remains unclear. We examined whether young adult METH users have shorter LTL and explored the relationship between characteristics of METH use and LTL by using Mendelian randomization (MR) analysis. We compared the LTL for 187 METH users and 159 healthy individuals aged between 25 and 34 years and examined the relationship of LTL with METH use variables (onset age, duration, and maximum frequency of METH use) by using regression analyses. In addition, 2-stage-least-squares (2SLS) MR was also performed to possibly avoid uncontrolled confounding between characteristics of METH use and LTL. We found METH users had significantly shorter LTL compared to controls. Multivariate regression analysis showed METH use was negatively associated with LTL (β = −0.36, P < .001). Among METH users, duration of METH use was negatively associated with LTL after adjustment (β = −0.002, P = .01). We identified a single nucleotide polymorphism (SNP) rs6585206 genome-wide associated with duration of METH use. This SNP was used as an instrumental variable to avoid uncontrolled confounding for the relationship between the use duration and LTL shortening. In conclusion, we show that young adult METH users may have shorter LTL compared with controls and longer duration of METH use was significantly associated with telomere shortening. These observations suggest that METH use may accelerate biological senescence. |
format | Online Article Text |
id | pubmed-8502172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-85021722021-10-22 Shortened leukocyte telomere length in young adults who use methamphetamine Lin, Yen-Feng Chen, Po-Yu Liu, Hsing-Cheng Chen, Yi-Lung Chou, Wei-Hern Huang, Ming-Chyi Transl Psychiatry Article Methamphetamine (METH) use, most prevalent in young adults, has been associated with high rates of morbidity and mortality. The relationship between METH use and accelerated biological aging, which can be measured using leukocyte telomere length (LTL), remains unclear. We examined whether young adult METH users have shorter LTL and explored the relationship between characteristics of METH use and LTL by using Mendelian randomization (MR) analysis. We compared the LTL for 187 METH users and 159 healthy individuals aged between 25 and 34 years and examined the relationship of LTL with METH use variables (onset age, duration, and maximum frequency of METH use) by using regression analyses. In addition, 2-stage-least-squares (2SLS) MR was also performed to possibly avoid uncontrolled confounding between characteristics of METH use and LTL. We found METH users had significantly shorter LTL compared to controls. Multivariate regression analysis showed METH use was negatively associated with LTL (β = −0.36, P < .001). Among METH users, duration of METH use was negatively associated with LTL after adjustment (β = −0.002, P = .01). We identified a single nucleotide polymorphism (SNP) rs6585206 genome-wide associated with duration of METH use. This SNP was used as an instrumental variable to avoid uncontrolled confounding for the relationship between the use duration and LTL shortening. In conclusion, we show that young adult METH users may have shorter LTL compared with controls and longer duration of METH use was significantly associated with telomere shortening. These observations suggest that METH use may accelerate biological senescence. Nature Publishing Group UK 2021-10-09 /pmc/articles/PMC8502172/ /pubmed/34628468 http://dx.doi.org/10.1038/s41398-021-01640-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Lin, Yen-Feng Chen, Po-Yu Liu, Hsing-Cheng Chen, Yi-Lung Chou, Wei-Hern Huang, Ming-Chyi Shortened leukocyte telomere length in young adults who use methamphetamine |
title | Shortened leukocyte telomere length in young adults who use methamphetamine |
title_full | Shortened leukocyte telomere length in young adults who use methamphetamine |
title_fullStr | Shortened leukocyte telomere length in young adults who use methamphetamine |
title_full_unstemmed | Shortened leukocyte telomere length in young adults who use methamphetamine |
title_short | Shortened leukocyte telomere length in young adults who use methamphetamine |
title_sort | shortened leukocyte telomere length in young adults who use methamphetamine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502172/ https://www.ncbi.nlm.nih.gov/pubmed/34628468 http://dx.doi.org/10.1038/s41398-021-01640-z |
work_keys_str_mv | AT linyenfeng shortenedleukocytetelomerelengthinyoungadultswhousemethamphetamine AT chenpoyu shortenedleukocytetelomerelengthinyoungadultswhousemethamphetamine AT liuhsingcheng shortenedleukocytetelomerelengthinyoungadultswhousemethamphetamine AT chenyilung shortenedleukocytetelomerelengthinyoungadultswhousemethamphetamine AT chouweihern shortenedleukocytetelomerelengthinyoungadultswhousemethamphetamine AT huangmingchyi shortenedleukocytetelomerelengthinyoungadultswhousemethamphetamine |