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AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice

Renal tubulointerstitial fibrosis was a crucial pathological feature of diabetic nephropathy (DN), and renal tubular injury might associate with abnormal mitophagy. In this study, we investigated the effects and molecular mechanisms of AMPK agonist metformin on mitophagy and cellular injury in renal...

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Detalles Bibliográficos
Autores principales:	Han, Ya-chun, Tang, Shi-qi, Liu, Yu-ting, Li, Ai-mei, Zhan, Ming, Yang, Ming, Song, Na, Zhang, Wei, Wu, Xue-qin, Peng, Can-hui, Zhang, Hao, Yang, Shikun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502176/ https://www.ncbi.nlm.nih.gov/pubmed/34628484 http://dx.doi.org/10.1038/s41419-021-04184-8

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