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Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum

BACKGROUND: Given that tau accumulation, not amyloid-β (Aβ) burden, is more closely connected with cognitive impairment in Alzheimer’s disease (AD), a detailed understanding of the tau-related characteristics of cognitive function is critical in both clinical and research settings. We investigated t...

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Autores principales: Seo, Eun Hyun, Lim, Ho Jae, Yoon, Hyung-Jun, Choi, Kyu Yeong, Lee, Jang Jae, Park, Jun Young, Choi, Seong Hye, Kim, Hoowon, Kim, Byeong C., Lee, Kun Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502282/
https://www.ncbi.nlm.nih.gov/pubmed/34627371
http://dx.doi.org/10.1186/s13195-021-00909-1
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author Seo, Eun Hyun
Lim, Ho Jae
Yoon, Hyung-Jun
Choi, Kyu Yeong
Lee, Jang Jae
Park, Jun Young
Choi, Seong Hye
Kim, Hoowon
Kim, Byeong C.
Lee, Kun Ho
author_facet Seo, Eun Hyun
Lim, Ho Jae
Yoon, Hyung-Jun
Choi, Kyu Yeong
Lee, Jang Jae
Park, Jun Young
Choi, Seong Hye
Kim, Hoowon
Kim, Byeong C.
Lee, Kun Ho
author_sort Seo, Eun Hyun
collection PubMed
description BACKGROUND: Given that tau accumulation, not amyloid-β (Aβ) burden, is more closely connected with cognitive impairment in Alzheimer’s disease (AD), a detailed understanding of the tau-related characteristics of cognitive function is critical in both clinical and research settings. We investigated the association between phosphorylated tau (p-Tau) level and cognitive impairment across the AD continuum and the mediating role of medial temporal lobe (MTL) atrophy. We also developed a prediction model for abnormal tau accumulation. METHODS: We included participants from the Gwangju Alzheimer’s Disease and Related Dementia Cohort in Korea, who completed cerebrospinal fluid analysis and clinical evaluation, and corresponded to one of three groups according to the biomarkers of A and T profiles based on the National Institute on Aging and Alzheimer’s Association research framework. Multiple linear and logistic regression analyses were performed to examine the association between p-Tau and cognition and to develop prediction models. Receiver operating characteristic curve analysis was performed to examine the discrimination ability of the models. RESULTS: Among 185 participants, 93 were classified as A-T-, 23 as A+T-, and 69 as A+T+. There was an association between decreased visuospatial delayed memory performance and p-Tau level (B = − 0.754, β = − 0.363, p < 0.001), independent of other relevant variables (e.g., Aβ). MTL neurodegeneration was found to mediate the association between the two. Prediction models with visuospatial delayed memory alone (area under the curve [AUC] = 0.872) and visuospatial delayed memory and entorhinal thickness (AUC = 0.921) for abnormal tau accumulation were suggested and they were validated in an independent sample (AUC = 0.879 and 0.891, respectively). CONCLUSION: It is crucial to identify sensitive cognitive measures that capture subtle cognitive impairment associated with underlying pathological changes. Preliminary findings from the current study might suggest that abnormal tau accumulation underlies episodic memory impairment, particularly visuospatial modality, in the AD continuum. Suggested models are potentially useful in predicting tau pathology, and might be utilized practically in the field. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-021-00909-1.
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spelling pubmed-85022822021-10-20 Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum Seo, Eun Hyun Lim, Ho Jae Yoon, Hyung-Jun Choi, Kyu Yeong Lee, Jang Jae Park, Jun Young Choi, Seong Hye Kim, Hoowon Kim, Byeong C. Lee, Kun Ho Alzheimers Res Ther Research BACKGROUND: Given that tau accumulation, not amyloid-β (Aβ) burden, is more closely connected with cognitive impairment in Alzheimer’s disease (AD), a detailed understanding of the tau-related characteristics of cognitive function is critical in both clinical and research settings. We investigated the association between phosphorylated tau (p-Tau) level and cognitive impairment across the AD continuum and the mediating role of medial temporal lobe (MTL) atrophy. We also developed a prediction model for abnormal tau accumulation. METHODS: We included participants from the Gwangju Alzheimer’s Disease and Related Dementia Cohort in Korea, who completed cerebrospinal fluid analysis and clinical evaluation, and corresponded to one of three groups according to the biomarkers of A and T profiles based on the National Institute on Aging and Alzheimer’s Association research framework. Multiple linear and logistic regression analyses were performed to examine the association between p-Tau and cognition and to develop prediction models. Receiver operating characteristic curve analysis was performed to examine the discrimination ability of the models. RESULTS: Among 185 participants, 93 were classified as A-T-, 23 as A+T-, and 69 as A+T+. There was an association between decreased visuospatial delayed memory performance and p-Tau level (B = − 0.754, β = − 0.363, p < 0.001), independent of other relevant variables (e.g., Aβ). MTL neurodegeneration was found to mediate the association between the two. Prediction models with visuospatial delayed memory alone (area under the curve [AUC] = 0.872) and visuospatial delayed memory and entorhinal thickness (AUC = 0.921) for abnormal tau accumulation were suggested and they were validated in an independent sample (AUC = 0.879 and 0.891, respectively). CONCLUSION: It is crucial to identify sensitive cognitive measures that capture subtle cognitive impairment associated with underlying pathological changes. Preliminary findings from the current study might suggest that abnormal tau accumulation underlies episodic memory impairment, particularly visuospatial modality, in the AD continuum. Suggested models are potentially useful in predicting tau pathology, and might be utilized practically in the field. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13195-021-00909-1. BioMed Central 2021-10-09 /pmc/articles/PMC8502282/ /pubmed/34627371 http://dx.doi.org/10.1186/s13195-021-00909-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Seo, Eun Hyun
Lim, Ho Jae
Yoon, Hyung-Jun
Choi, Kyu Yeong
Lee, Jang Jae
Park, Jun Young
Choi, Seong Hye
Kim, Hoowon
Kim, Byeong C.
Lee, Kun Ho
Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum
title Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum
title_full Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum
title_fullStr Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum
title_full_unstemmed Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum
title_short Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer’s continuum
title_sort visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in alzheimer’s continuum
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502282/
https://www.ncbi.nlm.nih.gov/pubmed/34627371
http://dx.doi.org/10.1186/s13195-021-00909-1
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