Cargando…

Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan

BACKGROUND: In July 1984, Taiwan officially began a nationwide hepatitis B virus (HBV) vaccination program where only infants born to HBsAg-positive mothers were vaccinated free of charge until June 1986. However, from July 1986, all infants were vaccinated against HBV. The impact of the July 1986 H...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Hsuan-Hui, Sun, Shu-Lung, Jau, Rong-Chiou, Tantoh, Disline Manli, Hsu, Shu-Yi, Nfor, Oswald Ndi, Chen, Pei-Hsin, Liu, Wen-Hsiu, Ko, Jiunn-Liang, Liaw, Yung-Po
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502303/
https://www.ncbi.nlm.nih.gov/pubmed/34627173
http://dx.doi.org/10.1186/s12889-021-11846-x
_version_ 1784580868328652800
author Wang, Hsuan-Hui
Sun, Shu-Lung
Jau, Rong-Chiou
Tantoh, Disline Manli
Hsu, Shu-Yi
Nfor, Oswald Ndi
Chen, Pei-Hsin
Liu, Wen-Hsiu
Ko, Jiunn-Liang
Liaw, Yung-Po
author_facet Wang, Hsuan-Hui
Sun, Shu-Lung
Jau, Rong-Chiou
Tantoh, Disline Manli
Hsu, Shu-Yi
Nfor, Oswald Ndi
Chen, Pei-Hsin
Liu, Wen-Hsiu
Ko, Jiunn-Liang
Liaw, Yung-Po
author_sort Wang, Hsuan-Hui
collection PubMed
description BACKGROUND: In July 1984, Taiwan officially began a nationwide hepatitis B virus (HBV) vaccination program where only infants born to HBsAg-positive mothers were vaccinated free of charge until June 1986. However, from July 1986, all infants were vaccinated against HBV. The impact of the July 1986 HBV vaccination program on first-time blood donors has not been exhaustively studied. We, therefore, determined the risk of HBV among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan. METHODS: Initially, we recruited 857,310 first-time blood donors whose data were collected between 2013 and 2018 from 5 blood donation centers in Taiwan. However, we excluded donors with incomplete and outlying data (n = 12,213) and those born between July 1984 and June 1986 (n = 21,054). The final study participants comprised 9118 HBV positive and 814,925 HBV negative individuals. We divided the participants into two birth cohorts (born before and after July 1986) and assumed that those born before July 1986 were not vaccinated at birth while those born after July 1986 were vaccinated. RESULTS: The prevalence of HBV among those born before and after July 1986 was 4.53 and 0.25%, respectively. Individuals born after July 1986 had a lower risk of HBV than those born before July 1986. The adjusted odds ratio (OR), 95% confidence interval (CI) was 0.16, 0.13–0.19. Men had a higher risk of HBV than women (OR = 1.40, 95% CI = 1.34–1.47). The interaction between sex and birth date was significant (p-value = 0.0067). Stratification of participants by birth date revealed a higher risk of HBV in men compared to women in both birth cohorts. The OR, 95% CI was 1.47, 1.40–1.55 for those born before July 1986 but declined to 1.15, 1.02–1.29 for those born after July 1986. CONCLUSIONS: The risk of HBV was lower among those born after than those born before the July 1986 vaccination program. In both cohorts, the risk was high in men relative to women. The seemingly protective effect among those born after July 1986 was higher in women than men.
format Online
Article
Text
id pubmed-8502303
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-85023032021-10-20 Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan Wang, Hsuan-Hui Sun, Shu-Lung Jau, Rong-Chiou Tantoh, Disline Manli Hsu, Shu-Yi Nfor, Oswald Ndi Chen, Pei-Hsin Liu, Wen-Hsiu Ko, Jiunn-Liang Liaw, Yung-Po BMC Public Health Research BACKGROUND: In July 1984, Taiwan officially began a nationwide hepatitis B virus (HBV) vaccination program where only infants born to HBsAg-positive mothers were vaccinated free of charge until June 1986. However, from July 1986, all infants were vaccinated against HBV. The impact of the July 1986 HBV vaccination program on first-time blood donors has not been exhaustively studied. We, therefore, determined the risk of HBV among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan. METHODS: Initially, we recruited 857,310 first-time blood donors whose data were collected between 2013 and 2018 from 5 blood donation centers in Taiwan. However, we excluded donors with incomplete and outlying data (n = 12,213) and those born between July 1984 and June 1986 (n = 21,054). The final study participants comprised 9118 HBV positive and 814,925 HBV negative individuals. We divided the participants into two birth cohorts (born before and after July 1986) and assumed that those born before July 1986 were not vaccinated at birth while those born after July 1986 were vaccinated. RESULTS: The prevalence of HBV among those born before and after July 1986 was 4.53 and 0.25%, respectively. Individuals born after July 1986 had a lower risk of HBV than those born before July 1986. The adjusted odds ratio (OR), 95% confidence interval (CI) was 0.16, 0.13–0.19. Men had a higher risk of HBV than women (OR = 1.40, 95% CI = 1.34–1.47). The interaction between sex and birth date was significant (p-value = 0.0067). Stratification of participants by birth date revealed a higher risk of HBV in men compared to women in both birth cohorts. The OR, 95% CI was 1.47, 1.40–1.55 for those born before July 1986 but declined to 1.15, 1.02–1.29 for those born after July 1986. CONCLUSIONS: The risk of HBV was lower among those born after than those born before the July 1986 vaccination program. In both cohorts, the risk was high in men relative to women. The seemingly protective effect among those born after July 1986 was higher in women than men. BioMed Central 2021-10-09 /pmc/articles/PMC8502303/ /pubmed/34627173 http://dx.doi.org/10.1186/s12889-021-11846-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Hsuan-Hui
Sun, Shu-Lung
Jau, Rong-Chiou
Tantoh, Disline Manli
Hsu, Shu-Yi
Nfor, Oswald Ndi
Chen, Pei-Hsin
Liu, Wen-Hsiu
Ko, Jiunn-Liang
Liaw, Yung-Po
Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan
title Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan
title_full Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan
title_fullStr Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan
title_full_unstemmed Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan
title_short Risk of HBV infection among male and female first-time blood donors born before and after the July 1986 HBV vaccination program in Taiwan
title_sort risk of hbv infection among male and female first-time blood donors born before and after the july 1986 hbv vaccination program in taiwan
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502303/
https://www.ncbi.nlm.nih.gov/pubmed/34627173
http://dx.doi.org/10.1186/s12889-021-11846-x
work_keys_str_mv AT wanghsuanhui riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT sunshulung riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT jaurongchiou riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT tantohdislinemanli riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT hsushuyi riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT nforoswaldndi riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT chenpeihsin riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT liuwenhsiu riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT kojiunnliang riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan
AT liawyungpo riskofhbvinfectionamongmaleandfemalefirsttimeblooddonorsbornbeforeandafterthejuly1986hbvvaccinationprogramintaiwan