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sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis

BACKGROUND: Tumor necrosis factor (TNF)-α inhibitors represented by Etanercept (a fusion protein containing soluble TNF receptor II (sTNFRII) and the Fc segment of human IgG1) play a pivotal role in Rheumatoid arthritis (RA) treatment. However, long-term use increases the risk of infection and tumor...

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Detalles Bibliográficos
Autores principales:	Zhao, Yingjie, Yang, Xuezhi, Li, Siyu, Zhang, Bingjie, Li, Susu, Wang, Xinwei, Wang, Yueye, Jia, Chengyan, Chang, Yan, Wei, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502322/ https://www.ncbi.nlm.nih.gov/pubmed/34627365 http://dx.doi.org/10.1186/s13287-021-02602-4

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