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Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report
BACKGROUND: Autoimmune diseases refers to a class of diseases involving abnormal immune response of human body and tissue damage caused by the dysregulation of autoimmune balance or destruction of immune tolerance. Recent research has revealed that the occurrence of autoimmune diseases is influenced...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502364/ https://www.ncbi.nlm.nih.gov/pubmed/34627357 http://dx.doi.org/10.1186/s13256-021-03092-x |
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author | Zhang, Lulu Ding, Dongxue Yu, Liqiang Qi, Huan Han, Chunru Jiang, Jianhua Jiang, Juean |
author_facet | Zhang, Lulu Ding, Dongxue Yu, Liqiang Qi, Huan Han, Chunru Jiang, Jianhua Jiang, Juean |
author_sort | Zhang, Lulu |
collection | PubMed |
description | BACKGROUND: Autoimmune diseases refers to a class of diseases involving abnormal immune response of human body and tissue damage caused by the dysregulation of autoimmune balance or destruction of immune tolerance. Recent research has revealed that the occurrence of autoimmune diseases is influenced by genetic, hormonal, immunological, and environmental factors. As sex hormone levels change obviously during pregnancy and postpartum, the morbidity and recurrence rate of autoimmune diseases increase during this period. CASE PRESENTATION: A 31-year-old Asian woman was admitted to our hospital for myasthenia gravis and treated with methylprednisolone and pyridostigmine bromide 3 months postpartum. Physical examination and laboratory inspection after admission suggested that the patient had primary biliary cirrhosis. Subsequently, azathioprine was added to the treatment, and the symptoms of both diseases were successfully controlled. CONCLUSIONS: This case exhibits a rare condition of myasthenia gravis combined with primary biliary cirrhosis postpartum. Given the fluctuation of the immune status during the postpartum period, combined autoimmune diseases need to be taken into account when patients develop clinical symptoms of an autoimmune disease. Therefore, detailed physical and laboratory examination can help to prevent the missed diagnosis of these diseases. |
format | Online Article Text |
id | pubmed-8502364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85023642021-10-20 Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report Zhang, Lulu Ding, Dongxue Yu, Liqiang Qi, Huan Han, Chunru Jiang, Jianhua Jiang, Juean J Med Case Rep Case Report BACKGROUND: Autoimmune diseases refers to a class of diseases involving abnormal immune response of human body and tissue damage caused by the dysregulation of autoimmune balance or destruction of immune tolerance. Recent research has revealed that the occurrence of autoimmune diseases is influenced by genetic, hormonal, immunological, and environmental factors. As sex hormone levels change obviously during pregnancy and postpartum, the morbidity and recurrence rate of autoimmune diseases increase during this period. CASE PRESENTATION: A 31-year-old Asian woman was admitted to our hospital for myasthenia gravis and treated with methylprednisolone and pyridostigmine bromide 3 months postpartum. Physical examination and laboratory inspection after admission suggested that the patient had primary biliary cirrhosis. Subsequently, azathioprine was added to the treatment, and the symptoms of both diseases were successfully controlled. CONCLUSIONS: This case exhibits a rare condition of myasthenia gravis combined with primary biliary cirrhosis postpartum. Given the fluctuation of the immune status during the postpartum period, combined autoimmune diseases need to be taken into account when patients develop clinical symptoms of an autoimmune disease. Therefore, detailed physical and laboratory examination can help to prevent the missed diagnosis of these diseases. BioMed Central 2021-10-10 /pmc/articles/PMC8502364/ /pubmed/34627357 http://dx.doi.org/10.1186/s13256-021-03092-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Zhang, Lulu Ding, Dongxue Yu, Liqiang Qi, Huan Han, Chunru Jiang, Jianhua Jiang, Juean Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report |
title | Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report |
title_full | Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report |
title_fullStr | Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report |
title_full_unstemmed | Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report |
title_short | Primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report |
title_sort | primary biliary cirrhosis associated with myasthenia gravis after postpartum: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502364/ https://www.ncbi.nlm.nih.gov/pubmed/34627357 http://dx.doi.org/10.1186/s13256-021-03092-x |
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