Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information

BACKGROUND: Osteosarcoma (OSA) is a devastating disease that is common in the Irish Wolfhound breed. The aim of this study was to use a pedigree-based approach to determine the heritability of OSA in the Irish Wolfhound using data from a large publically available database. RESULTS: The pedigree use...

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Autores principales: Momen, Mehdi, Kohler, Nyah L., Binversie, Emily E., Dentino, Mariellen, Sample, Susannah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502365/
https://www.ncbi.nlm.nih.gov/pubmed/34627404
http://dx.doi.org/10.1186/s40575-021-00109-y
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author Momen, Mehdi
Kohler, Nyah L.
Binversie, Emily E.
Dentino, Mariellen
Sample, Susannah J.
author_facet Momen, Mehdi
Kohler, Nyah L.
Binversie, Emily E.
Dentino, Mariellen
Sample, Susannah J.
author_sort Momen, Mehdi
collection PubMed
description BACKGROUND: Osteosarcoma (OSA) is a devastating disease that is common in the Irish Wolfhound breed. The aim of this study was to use a pedigree-based approach to determine the heritability of OSA in the Irish Wolfhound using data from a large publically available database. RESULTS: The pedigree used for this study included 5110 pure-bred Irish Wolfhounds, including 332 dogs diagnosed with OSA and 360 control dogs; dogs were considered controls if they lived over 10 years of age and were not reported to have developed OSA. The estimated heritability of OSA in the Irish Wolfhound was 0.65. CONCLUSION: The results of this study indicate that OSA in the Irish Wolfhound is highly heritable, and support the need for future research investigating associated genetic mutations.
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spelling pubmed-85023652021-10-20 Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information Momen, Mehdi Kohler, Nyah L. Binversie, Emily E. Dentino, Mariellen Sample, Susannah J. Canine Med Genet Research BACKGROUND: Osteosarcoma (OSA) is a devastating disease that is common in the Irish Wolfhound breed. The aim of this study was to use a pedigree-based approach to determine the heritability of OSA in the Irish Wolfhound using data from a large publically available database. RESULTS: The pedigree used for this study included 5110 pure-bred Irish Wolfhounds, including 332 dogs diagnosed with OSA and 360 control dogs; dogs were considered controls if they lived over 10 years of age and were not reported to have developed OSA. The estimated heritability of OSA in the Irish Wolfhound was 0.65. CONCLUSION: The results of this study indicate that OSA in the Irish Wolfhound is highly heritable, and support the need for future research investigating associated genetic mutations. BioMed Central 2021-10-09 /pmc/articles/PMC8502365/ /pubmed/34627404 http://dx.doi.org/10.1186/s40575-021-00109-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Momen, Mehdi
Kohler, Nyah L.
Binversie, Emily E.
Dentino, Mariellen
Sample, Susannah J.
Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information
title Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information
title_full Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information
title_fullStr Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information
title_full_unstemmed Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information
title_short Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information
title_sort heritability and genetic variance estimation of osteosarcoma (osa) in irish wolfhound, using deep pedigree information
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502365/
https://www.ncbi.nlm.nih.gov/pubmed/34627404
http://dx.doi.org/10.1186/s40575-021-00109-y
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