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Targeting microRNAs with thymoquinone: a new approach for cancer therapy
Cancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy and/or surgery for cancer treatment. Since one in six deaths is due to cancer, it is one of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502376/ https://www.ncbi.nlm.nih.gov/pubmed/34627167 http://dx.doi.org/10.1186/s11658-021-00286-5 |
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author | Homayoonfal, Mina Asemi, Zatollah Yousefi, Bahman |
author_facet | Homayoonfal, Mina Asemi, Zatollah Yousefi, Bahman |
author_sort | Homayoonfal, Mina |
collection | PubMed |
description | Cancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy and/or surgery for cancer treatment. Since one in six deaths is due to cancer, it is one of the overriding priorities of world health. Recently, bioactive natural compounds have been widely recognized due to their therapeutic effects for treatment of various chronic disorders, notably cancer. Thymoquinone (TQ), the most valuable constituent of black cumin seeds, has shown anti-cancer characteristics in a wide range of animal models. The revolutionary findings have revealed TQ’s ability to regulate microRNA (miRNA) expression, offering a promising approach for cancer therapy. MiRNAs are small noncoding RNAs that modulate gene expression by means of variation in features of mRNA. MiRNAs manage several biological processes including gene expression and cellular signaling pathways. Accordingly, miRNAs can be considered as hallmarks for cancer diagnosis, prognosis and therapy. The purpose of this study was to review the various molecular mechanisms by which TQ exerts its potential as an anti-cancer agent through modulating miRNAs. |
format | Online Article Text |
id | pubmed-8502376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-85023762021-10-20 Targeting microRNAs with thymoquinone: a new approach for cancer therapy Homayoonfal, Mina Asemi, Zatollah Yousefi, Bahman Cell Mol Biol Lett Review Cancer is a global disease involving transformation of normal cells into tumor types via numerous mechanisms, with mortality among all generations, in spite of the breakthroughs in chemotherapy, radiotherapy and/or surgery for cancer treatment. Since one in six deaths is due to cancer, it is one of the overriding priorities of world health. Recently, bioactive natural compounds have been widely recognized due to their therapeutic effects for treatment of various chronic disorders, notably cancer. Thymoquinone (TQ), the most valuable constituent of black cumin seeds, has shown anti-cancer characteristics in a wide range of animal models. The revolutionary findings have revealed TQ’s ability to regulate microRNA (miRNA) expression, offering a promising approach for cancer therapy. MiRNAs are small noncoding RNAs that modulate gene expression by means of variation in features of mRNA. MiRNAs manage several biological processes including gene expression and cellular signaling pathways. Accordingly, miRNAs can be considered as hallmarks for cancer diagnosis, prognosis and therapy. The purpose of this study was to review the various molecular mechanisms by which TQ exerts its potential as an anti-cancer agent through modulating miRNAs. BioMed Central 2021-10-09 /pmc/articles/PMC8502376/ /pubmed/34627167 http://dx.doi.org/10.1186/s11658-021-00286-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Homayoonfal, Mina Asemi, Zatollah Yousefi, Bahman Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
title | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
title_full | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
title_fullStr | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
title_full_unstemmed | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
title_short | Targeting microRNAs with thymoquinone: a new approach for cancer therapy |
title_sort | targeting micrornas with thymoquinone: a new approach for cancer therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502376/ https://www.ncbi.nlm.nih.gov/pubmed/34627167 http://dx.doi.org/10.1186/s11658-021-00286-5 |
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