Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats

The unbound concentrations of 14 commercial drugs, including five non‐efflux/uptake transporter substrates—Class I, five efflux transporter substrates—class II and four influx transporter substrates—Class III, were simultaneously measured in rat liver, muscle, and blood via microanalysis. K (puu,liv...

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Detalles Bibliográficos
Autores principales: Wang, Shuyao, Chen, Chun, Guan, Chi, Qiu, Liping, Zhang, Lei, Zhang, Shaofeng, Zhou, Hongyu, Du, Hongwen, Li, Chen, Wu, Yaqiong, Chang, Hang, Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502442/
https://www.ncbi.nlm.nih.gov/pubmed/34628723
http://dx.doi.org/10.1002/prp2.879

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