Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy

Pseudo-progression is a phenomenon induced by treatment with immune checkpoint inhibitors and is characterized by an increase in tumor size or the appearance of new lesions, followed by tumor regression. However, life-threatening conditions, such as cardiac tamponade, can develop in such patients. W...

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Autores principales: Nakashima, Koki, Demura, Yoshiki, Sato, Masayuki, Fujii, Yuya, Igarashi, Kazunari, Ishizuka, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502658/
https://www.ncbi.nlm.nih.gov/pubmed/33814492
http://dx.doi.org/10.2169/internalmedicine.6509-20
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author Nakashima, Koki
Demura, Yoshiki
Sato, Masayuki
Fujii, Yuya
Igarashi, Kazunari
Ishizuka, Tamotsu
author_facet Nakashima, Koki
Demura, Yoshiki
Sato, Masayuki
Fujii, Yuya
Igarashi, Kazunari
Ishizuka, Tamotsu
author_sort Nakashima, Koki
collection PubMed
description Pseudo-progression is a phenomenon induced by treatment with immune checkpoint inhibitors and is characterized by an increase in tumor size or the appearance of new lesions, followed by tumor regression. However, life-threatening conditions, such as cardiac tamponade, can develop in such patients. We herein report on a 69-year-old man with lung adenocarcinoma who developed cardiac tamponade as a manifestation of pseudo-progression induced by treatment with atezolizumab combined with cytotoxic chemotherapy. After managing the cardiac tamponade, atezolizumab was successfully re-administered along with cytotoxic chemotherapy without disease progression.
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spelling pubmed-85026582021-10-26 Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy Nakashima, Koki Demura, Yoshiki Sato, Masayuki Fujii, Yuya Igarashi, Kazunari Ishizuka, Tamotsu Intern Med Case Report Pseudo-progression is a phenomenon induced by treatment with immune checkpoint inhibitors and is characterized by an increase in tumor size or the appearance of new lesions, followed by tumor regression. However, life-threatening conditions, such as cardiac tamponade, can develop in such patients. We herein report on a 69-year-old man with lung adenocarcinoma who developed cardiac tamponade as a manifestation of pseudo-progression induced by treatment with atezolizumab combined with cytotoxic chemotherapy. After managing the cardiac tamponade, atezolizumab was successfully re-administered along with cytotoxic chemotherapy without disease progression. The Japanese Society of Internal Medicine 2021-04-05 2021-09-15 /pmc/articles/PMC8502658/ /pubmed/33814492 http://dx.doi.org/10.2169/internalmedicine.6509-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakashima, Koki
Demura, Yoshiki
Sato, Masayuki
Fujii, Yuya
Igarashi, Kazunari
Ishizuka, Tamotsu
Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
title Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
title_full Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
title_fullStr Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
title_full_unstemmed Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
title_short Successful Re-administration of Atezolizumab for a Non-small-cell Lung Cancer Patient after Cardiac Tamponade Development as a Manifestation of Pseudo-progression Induced by Combination Treatment with Atezolizumab and Cytotoxic Chemotherapy
title_sort successful re-administration of atezolizumab for a non-small-cell lung cancer patient after cardiac tamponade development as a manifestation of pseudo-progression induced by combination treatment with atezolizumab and cytotoxic chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502658/
https://www.ncbi.nlm.nih.gov/pubmed/33814492
http://dx.doi.org/10.2169/internalmedicine.6509-20
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