Cargando…

Towards Fixed Dosing of Tocilizumab in ICU-Admitted COVID-19 Patients: Results of an Observational Population Pharmacokinetic and Descriptive Pharmacodynamic Study

BACKGROUND AND OBJECTIVE: In the randomized controlled trial REMAP-CAP, it was shown that next to dexamethasone, the interleukin (IL)-6 receptor antagonist tocilizumab improves outcome, including survival in intensive care unit (ICU)-admitted coronavirus disease 2019 (COVID)-19 patients. Therefore t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moes, Dirk Jan A. R., van Westerloo, David J., Arend, Sandra M., Swen, Jesse J., de Vries, Annick, Guchelaar, Henk-Jan, Joosten, Simone A., de Boer, Mark G. J., van Gelder, Teun, van Paassen, Judith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502793/ https://www.ncbi.nlm.nih.gov/pubmed/34633645 http://dx.doi.org/10.1007/s40262-021-01074-2

Ejemplares similares

Tamoxifen pharmacokinetics and pharmacodynamics in older patients with non-metastatic breast cancer
por: Souwer, E. T. D., et al.
Publicado: (2023)

Comparison of the Impact of Pharmacogenetic Variability on the PK of Slow Release and Immediate Release Tacrolimus Formulations
por: van Gelder, Teun, et al.
Publicado: (2020)

The Clinical Impact of the C(0)/D Ratio and the CYP3A5 Genotype on Outcome in Tacrolimus Treated Kidney Transplant Recipients
por: van Gelder, Teun, et al.
Publicado: (2020)

A Review of Mathematical Models for Tumor Dynamics and Treatment Resistance Evolution of Solid Tumors
por: Yin, Anyue, et al.
Publicado: (2019)

Tocilizumab in ICU-admitted COVID-19 Patients: A Retrospective Study
por: Siami, Zeinab, et al.
Publicado: (2023)

Technologies for Pharmacogenomics: A Review
por: van der Lee, Maaike, et al.
Publicado: (2020)

Genetic polymorphisms of 3′-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy
por: Sanchez-Spitman, A. B., et al.
Publicado: (2018)

Volumetric microsampling for simultaneous remote immunosuppressant and kidney function monitoring in outpatient kidney transplant recipients
por: Zwart, Tom C., et al.
Publicado: (2022)

Review of the Clinical Pharmacokinetics and Pharmacodynamics of Alemtuzumab and Its Use in Kidney Transplantation
por: van der Zwan, Marieke, et al.
Publicado: (2017)

Clinical Pharmacokinetics and Pharmacodynamics of the Epidermal Growth Factor Receptor Inhibitor Panitumumab in the Treatment of Colorectal Cancer
por: Ketzer, Sander, et al.
Publicado: (2017)

Tocilizumab Outcomes in Critically Ill COVID-19 Patients Admitted to the ICU and the Role of Non-Tocilizumab COVID-19-Specific Medical Therapeutics
por: Elhazmi, Alyaa, et al.
Publicado: (2023)

Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors
por: Centanni, Maddalena, et al.
Publicado: (2019)

Beliefs and actual practice of oxygen therapy in the ICU
por: Helmerhorst, HJ, et al.
Publicado: (2013)

Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines
por: Manson, Lisanne E. N., et al.
Publicado: (2020)

Exposure–response analysis of endoxifen serum concentrations in early-breast cancer
por: Sanchez-Spitman, Anabel Beatriz, et al.
Publicado: (2020)

Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity
por: Zhai, Qinglian, et al.
Publicado: (2022)

Systematic screening for COVID‐19 associated invasive aspergillosis in ICU patients by culture and PCR on tracheal aspirate
por: van Grootveld, Rebecca, et al.
Publicado: (2021)

Cost-Effectiveness of Pharmacogenomics-Guided Prescribing to Prevent Gene-Drug-Related Deaths: A Decision-Analytic Model
por: van der Wouden, Cathelijne H., et al.
Publicado: (2022)

Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance
por: Yin, Anyue, et al.
Publicado: (2022)

Publisher Correction: Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance
por: Yin, Anyue, et al.
Publicado: (2022)

Pharmacist-Initiated Pre-Emptive Pharmacogenetic Panel Testing with Clinical Decision Support in Primary Care: Record of PGx Results and Real-World Impact
por: van der Wouden, Cathelijne H., et al.
Publicado: (2019)

Application of long-read sequencing to elucidate complex pharmacogenomic regions: a proof of principle
por: van der Lee, Maaike, et al.
Publicado: (2021)

Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review
por: Klomp, Sylvia D., et al.
Publicado: (2020)

Intra-abdominal hypertension and abdominal compartment syndrome in patients admitted to the ICU
por: Smit, Marije, et al.
Publicado: (2020)

Applying Next-Generation Sequencing Platforms for Pharmacogenomic Testing in Clinical Practice
por: Tafazoli, Alireza, et al.
Publicado: (2021)

Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib
por: Hussaarts, Koen G. A. M., et al.
Publicado: (2020)

Pharmacokinetic/Pharmacodynamic Considerations of Alternate Dosing Strategies of Tocilizumab in COVID-19
por: Leung, Elizabeth, et al.
Publicado: (2021)

Assessing the Implementation of Pharmacogenomic Panel-Testing in Primary Care in the Netherlands Utilizing a Theoretical Framework
por: van der Wouden, Cathelijne H., et al.
Publicado: (2020)

Prognosis of patients with haematological malignancies admitted to the ICU
por: Geerse, DA, et al.
Publicado: (2008)

Model-Based Estimation of Iohexol Plasma Clearance for Pragmatic Renal Function Determination in the Renal Transplantation Setting
por: Zwart, Tom C., et al.
Publicado: (2021)

Volume of oxygen administered during mechanical ventilation predicts mortality in ICU patients
por: Grim, C. C. A., et al.
Publicado: (2023)

Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib‐Treated Cancer
por: Diekstra, MH, et al.
Publicado: (2017)

Self-reported attitudes versus actual practice of oxygen therapy by ICU physicians and nurses
por: Helmerhorst, Hendrik JF, et al.
Publicado: (2014)

Model-Informed Precision Dosing of Everolimus: External Validation in Adult Renal Transplant Recipients
por: Zwart, Tom C., et al.
Publicado: (2020)

Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab
por: Wijnsma, Kioa Lente, et al.
Publicado: (2019)

Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients
por: Franken, Linda G., et al.
Publicado: (2017)

Do-not-intubate status and COVID-19 mortality in patients admitted to Dutch non-ICU wards
por: van der Veer, Tjeerd, et al.
Publicado: (2021)

A comparison of the effectiveness of different doses of tocilizumab and sarilumab in the treatment of severe COVID-19: a natural experiment due to drug shortages()
por: Swets, Maaike C., et al.
Publicado: (2023)

The role of organizational characteristics on the outcome of COVID-19 patients admitted to the ICU in Belgium
por: Taccone, Fabio Silvio, et al.
Publicado: (2020)

Liver and kidney function in patients with Covid‐19 treated with remdesivir
por: van Laar, Sylvia A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dbpiinua5p6aug17gpamaa2usr