Cargando…
Mitochondrial Regulation of Diabetic Kidney Disease
The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondr...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502854/ https://www.ncbi.nlm.nih.gov/pubmed/34646847 http://dx.doi.org/10.3389/fmed.2021.745279 |
_version_ | 1784580981279162368 |
---|---|
author | Galvan, Daniel L. Mise, Koki Danesh, Farhad R. |
author_facet | Galvan, Daniel L. Mise, Koki Danesh, Farhad R. |
author_sort | Galvan, Daniel L. |
collection | PubMed |
description | The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondrial morphology to significant alterations in mitochondrial biogenesis, biosynthetic, bioenergetics and production of reactive oxygen species (ROS). How these changes individually or in aggregate contribute to progression of DKD remain to be fully elucidated. Nevertheless, because of the remarkable progress in our basic understanding of the role of mitochondrial biology and its dysfunction in DKD, there is great excitement on future targeted therapies based on improving mitochondrial function in DKD. This review will highlight the latest advances in understanding the nature of mitochondria dysfunction and its role in progression of DKD, and the development of mitochondrial targets that could be potentially used to prevent its progression. |
format | Online Article Text |
id | pubmed-8502854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85028542021-10-12 Mitochondrial Regulation of Diabetic Kidney Disease Galvan, Daniel L. Mise, Koki Danesh, Farhad R. Front Med (Lausanne) Medicine The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondrial morphology to significant alterations in mitochondrial biogenesis, biosynthetic, bioenergetics and production of reactive oxygen species (ROS). How these changes individually or in aggregate contribute to progression of DKD remain to be fully elucidated. Nevertheless, because of the remarkable progress in our basic understanding of the role of mitochondrial biology and its dysfunction in DKD, there is great excitement on future targeted therapies based on improving mitochondrial function in DKD. This review will highlight the latest advances in understanding the nature of mitochondria dysfunction and its role in progression of DKD, and the development of mitochondrial targets that could be potentially used to prevent its progression. Frontiers Media S.A. 2021-09-27 /pmc/articles/PMC8502854/ /pubmed/34646847 http://dx.doi.org/10.3389/fmed.2021.745279 Text en Copyright © 2021 Galvan, Mise and Danesh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Galvan, Daniel L. Mise, Koki Danesh, Farhad R. Mitochondrial Regulation of Diabetic Kidney Disease |
title | Mitochondrial Regulation of Diabetic Kidney Disease |
title_full | Mitochondrial Regulation of Diabetic Kidney Disease |
title_fullStr | Mitochondrial Regulation of Diabetic Kidney Disease |
title_full_unstemmed | Mitochondrial Regulation of Diabetic Kidney Disease |
title_short | Mitochondrial Regulation of Diabetic Kidney Disease |
title_sort | mitochondrial regulation of diabetic kidney disease |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502854/ https://www.ncbi.nlm.nih.gov/pubmed/34646847 http://dx.doi.org/10.3389/fmed.2021.745279 |
work_keys_str_mv | AT galvandaniell mitochondrialregulationofdiabetickidneydisease AT misekoki mitochondrialregulationofdiabetickidneydisease AT daneshfarhadr mitochondrialregulationofdiabetickidneydisease |