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Exploring Peritumoral Neural Tracts by Using Neurite Orientation Dispersion and Density Imaging
Diffusion Tensor Imaging (DTI) tractography has been widely used in brain tumor surgery to ensure thorough resection and minimize functional damage. However, due to enhanced anisotropic uncertainty in the area with peritumoral edema, diffusion tractography is generally not practicable leading to hig...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502884/ https://www.ncbi.nlm.nih.gov/pubmed/34646116 http://dx.doi.org/10.3389/fnins.2021.702353 |
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author | Chong, Shin Tai Liu, Xinrui Kao, Hung-Wen Lin, Chien-Yuan Eddy Hsu, Chih-Chin Heather Kung, Yi-Chia Kuo, Kuan-Tsen Huang, Chu-Chung Lo, Chun-Yi Zac Li, Yunqian Zhao, Gang Lin, Ching-Po |
author_facet | Chong, Shin Tai Liu, Xinrui Kao, Hung-Wen Lin, Chien-Yuan Eddy Hsu, Chih-Chin Heather Kung, Yi-Chia Kuo, Kuan-Tsen Huang, Chu-Chung Lo, Chun-Yi Zac Li, Yunqian Zhao, Gang Lin, Ching-Po |
author_sort | Chong, Shin Tai |
collection | PubMed |
description | Diffusion Tensor Imaging (DTI) tractography has been widely used in brain tumor surgery to ensure thorough resection and minimize functional damage. However, due to enhanced anisotropic uncertainty in the area with peritumoral edema, diffusion tractography is generally not practicable leading to high false-negative results in neural tracking. In this study, we evaluated the usefulness of the neurite orientation dispersion and density imaging (NODDI) derived tractography for investigating structural heterogeneity of the brain in patients with brain tumor. A total of 24 patients with brain tumors, characterized by peritumoral edema, and 10 healthy counterparts were recruited from 2014 to 2021. All participants underwent magnetic resonance imaging. Moreover, we used the images obtained from the healthy participants for calibrating the orientation dispersion threshold for NODDI-derived corticospinal tract (CST) reconstruction. Compared to DTI, NODDI-derived tractography has a great potential to improve the reconstruction of fiber tracking through regions of vasogenic edema. The regions with edematous CST in NODDI-derived tractography demonstrated a significant decrease in the intracellular volume fraction (VF(ic), p < 0.000) and an increase in the isotropic volume fraction (VF(iso), p < 0.014). Notably, the percentage of the involved volume of the concealed CST and lesion-to-tract distance could reflect the motor function of the patients. After the tumor resection, four patients with 1–5 years follow-up were showed subsidence of the vasogenic edema and normal CST on DTI tractography. NODDI-derived tractography revealed tracts within the edematous area and could assist neurosurgeons to locate the neural tracts that are otherwise not visualized by conventional DTI tractography. |
format | Online Article Text |
id | pubmed-8502884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85028842021-10-12 Exploring Peritumoral Neural Tracts by Using Neurite Orientation Dispersion and Density Imaging Chong, Shin Tai Liu, Xinrui Kao, Hung-Wen Lin, Chien-Yuan Eddy Hsu, Chih-Chin Heather Kung, Yi-Chia Kuo, Kuan-Tsen Huang, Chu-Chung Lo, Chun-Yi Zac Li, Yunqian Zhao, Gang Lin, Ching-Po Front Neurosci Neuroscience Diffusion Tensor Imaging (DTI) tractography has been widely used in brain tumor surgery to ensure thorough resection and minimize functional damage. However, due to enhanced anisotropic uncertainty in the area with peritumoral edema, diffusion tractography is generally not practicable leading to high false-negative results in neural tracking. In this study, we evaluated the usefulness of the neurite orientation dispersion and density imaging (NODDI) derived tractography for investigating structural heterogeneity of the brain in patients with brain tumor. A total of 24 patients with brain tumors, characterized by peritumoral edema, and 10 healthy counterparts were recruited from 2014 to 2021. All participants underwent magnetic resonance imaging. Moreover, we used the images obtained from the healthy participants for calibrating the orientation dispersion threshold for NODDI-derived corticospinal tract (CST) reconstruction. Compared to DTI, NODDI-derived tractography has a great potential to improve the reconstruction of fiber tracking through regions of vasogenic edema. The regions with edematous CST in NODDI-derived tractography demonstrated a significant decrease in the intracellular volume fraction (VF(ic), p < 0.000) and an increase in the isotropic volume fraction (VF(iso), p < 0.014). Notably, the percentage of the involved volume of the concealed CST and lesion-to-tract distance could reflect the motor function of the patients. After the tumor resection, four patients with 1–5 years follow-up were showed subsidence of the vasogenic edema and normal CST on DTI tractography. NODDI-derived tractography revealed tracts within the edematous area and could assist neurosurgeons to locate the neural tracts that are otherwise not visualized by conventional DTI tractography. Frontiers Media S.A. 2021-09-27 /pmc/articles/PMC8502884/ /pubmed/34646116 http://dx.doi.org/10.3389/fnins.2021.702353 Text en Copyright © 2021 Chong, Liu, Kao, Lin, Hsu, Kung, Kuo, Huang, Lo, Li, Zhao and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Chong, Shin Tai Liu, Xinrui Kao, Hung-Wen Lin, Chien-Yuan Eddy Hsu, Chih-Chin Heather Kung, Yi-Chia Kuo, Kuan-Tsen Huang, Chu-Chung Lo, Chun-Yi Zac Li, Yunqian Zhao, Gang Lin, Ching-Po Exploring Peritumoral Neural Tracts by Using Neurite Orientation Dispersion and Density Imaging |
title | Exploring Peritumoral Neural Tracts by Using Neurite Orientation Dispersion and Density Imaging |
title_full | Exploring Peritumoral Neural Tracts by Using Neurite Orientation Dispersion and Density Imaging |
title_fullStr | Exploring Peritumoral Neural Tracts by Using Neurite Orientation Dispersion and Density Imaging |
title_full_unstemmed | Exploring Peritumoral Neural Tracts by Using Neurite Orientation Dispersion and Density Imaging |
title_short | Exploring Peritumoral Neural Tracts by Using Neurite Orientation Dispersion and Density Imaging |
title_sort | exploring peritumoral neural tracts by using neurite orientation dispersion and density imaging |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502884/ https://www.ncbi.nlm.nih.gov/pubmed/34646116 http://dx.doi.org/10.3389/fnins.2021.702353 |
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