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Potential Effects of Coronaviruses on the Liver: An Update

The coronaviruses that cause notable diseases, namely, severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19), exhibit remarkable similarities in genomic components and pathogenetic mechanisms. Although coronaviruses have widely been...

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Autores principales: Wang, Xinyi, Lei, Jianyong, Li, Zhihui, Yan, Lunan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502894/
https://www.ncbi.nlm.nih.gov/pubmed/34646834
http://dx.doi.org/10.3389/fmed.2021.651658
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author Wang, Xinyi
Lei, Jianyong
Li, Zhihui
Yan, Lunan
author_facet Wang, Xinyi
Lei, Jianyong
Li, Zhihui
Yan, Lunan
author_sort Wang, Xinyi
collection PubMed
description The coronaviruses that cause notable diseases, namely, severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19), exhibit remarkable similarities in genomic components and pathogenetic mechanisms. Although coronaviruses have widely been studied as respiratory tract pathogens, their effects on the hepatobiliary system have seldom been reported. Overall, the manifestations of liver injury caused by coronaviruses typically involve decreased albumin and elevated aminotransferase and bilirubin levels. Several pathophysiological hypotheses have been proposed, including direct damage, immune-mediated injury, ischemia and hypoxia, thrombosis and drug hepatotoxicity. The interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. Drugs and vaccines used for treating and preventing coronavirus infection also have hepatotoxicity. Currently, the establishment of optimized therapy for coronavirus infection and liver disease comorbidity is of significance, warranting further safety tests, animal trials and clinical trials.
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spelling pubmed-85028942021-10-12 Potential Effects of Coronaviruses on the Liver: An Update Wang, Xinyi Lei, Jianyong Li, Zhihui Yan, Lunan Front Med (Lausanne) Medicine The coronaviruses that cause notable diseases, namely, severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS) and coronavirus disease 2019 (COVID-19), exhibit remarkable similarities in genomic components and pathogenetic mechanisms. Although coronaviruses have widely been studied as respiratory tract pathogens, their effects on the hepatobiliary system have seldom been reported. Overall, the manifestations of liver injury caused by coronaviruses typically involve decreased albumin and elevated aminotransferase and bilirubin levels. Several pathophysiological hypotheses have been proposed, including direct damage, immune-mediated injury, ischemia and hypoxia, thrombosis and drug hepatotoxicity. The interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. Drugs and vaccines used for treating and preventing coronavirus infection also have hepatotoxicity. Currently, the establishment of optimized therapy for coronavirus infection and liver disease comorbidity is of significance, warranting further safety tests, animal trials and clinical trials. Frontiers Media S.A. 2021-09-27 /pmc/articles/PMC8502894/ /pubmed/34646834 http://dx.doi.org/10.3389/fmed.2021.651658 Text en Copyright © 2021 Wang, Lei, Li and Yan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wang, Xinyi
Lei, Jianyong
Li, Zhihui
Yan, Lunan
Potential Effects of Coronaviruses on the Liver: An Update
title Potential Effects of Coronaviruses on the Liver: An Update
title_full Potential Effects of Coronaviruses on the Liver: An Update
title_fullStr Potential Effects of Coronaviruses on the Liver: An Update
title_full_unstemmed Potential Effects of Coronaviruses on the Liver: An Update
title_short Potential Effects of Coronaviruses on the Liver: An Update
title_sort potential effects of coronaviruses on the liver: an update
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502894/
https://www.ncbi.nlm.nih.gov/pubmed/34646834
http://dx.doi.org/10.3389/fmed.2021.651658
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