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LPA(1)-mediated PKD2 activation promotes LPA-induced tissue factor expression via the p38α and JNK2 MAPK pathways in smooth muscle cells

Tissue factor (TF) is the principal initiator of blood coagulation and is necessary for thrombosis. We previously reported that lysophosphatidic acid (LPA), a potent bioactive lipid, highly induces TF expression at the transcriptional level in vascular smooth muscle cells. To date, however, the spec...

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Detalles Bibliográficos
Autores principales:	Hao, Feng, Liu, Qiwei, Zhang, Fuqiang, Du, Jiaxin, Dumire, Amanda, Xu, Xuemin, Cui, Mei-Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502912/ https://www.ncbi.nlm.nih.gov/pubmed/34478715 http://dx.doi.org/10.1016/j.jbc.2021.101152

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