In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System

Absorption contrast between the terahertz (THz) frequency range of fatty and cancer tissues allows cancer diagnosis by THz imaging. We successfully demonstrated the ability of THz imaging to measure small breast cancer volume in the subcutaneous xenotransplantation mouse models even without external...

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Autores principales: Chen, Hua, Han, Juan, Wang, Dan, Zhang, Yu, Li, Xiao, Chen, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502942/
https://www.ncbi.nlm.nih.gov/pubmed/34646298
http://dx.doi.org/10.3389/fgene.2021.700086
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author Chen, Hua
Han, Juan
Wang, Dan
Zhang, Yu
Li, Xiao
Chen, Xiaofeng
author_facet Chen, Hua
Han, Juan
Wang, Dan
Zhang, Yu
Li, Xiao
Chen, Xiaofeng
author_sort Chen, Hua
collection PubMed
description Absorption contrast between the terahertz (THz) frequency range of fatty and cancer tissues allows cancer diagnosis by THz imaging. We successfully demonstrated the ability of THz imaging to measure small breast cancer volume in the subcutaneous xenotransplantation mouse models even without external comparison. We estimated the volume detection limitation of the fiber-based THz scanning imaging system using a highly sensitive cryogenic-temperature-operated Schottky diode detector to be smaller than 1 mm(3), thus showing the potential application of this technique in preliminary early cancer diagnosis.
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spelling pubmed-85029422021-10-12 In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System Chen, Hua Han, Juan Wang, Dan Zhang, Yu Li, Xiao Chen, Xiaofeng Front Genet Genetics Absorption contrast between the terahertz (THz) frequency range of fatty and cancer tissues allows cancer diagnosis by THz imaging. We successfully demonstrated the ability of THz imaging to measure small breast cancer volume in the subcutaneous xenotransplantation mouse models even without external comparison. We estimated the volume detection limitation of the fiber-based THz scanning imaging system using a highly sensitive cryogenic-temperature-operated Schottky diode detector to be smaller than 1 mm(3), thus showing the potential application of this technique in preliminary early cancer diagnosis. Frontiers Media S.A. 2021-09-27 /pmc/articles/PMC8502942/ /pubmed/34646298 http://dx.doi.org/10.3389/fgene.2021.700086 Text en Copyright © 2021 Chen, Han, Wang, Zhang, Li and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Chen, Hua
Han, Juan
Wang, Dan
Zhang, Yu
Li, Xiao
Chen, Xiaofeng
In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_full In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_fullStr In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_full_unstemmed In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_short In vivo Estimation of Breast Cancer Tissue Volume in Subcutaneous Xenotransplantation Mouse Models by Using a High-Sensitivity Fiber-Based Terahertz Scanning Imaging System
title_sort in vivo estimation of breast cancer tissue volume in subcutaneous xenotransplantation mouse models by using a high-sensitivity fiber-based terahertz scanning imaging system
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502942/
https://www.ncbi.nlm.nih.gov/pubmed/34646298
http://dx.doi.org/10.3389/fgene.2021.700086
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