Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

BACKGROUND: Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice and disruption of pyruvate kinase M2 (PKM2) activity is critical herein. Glutathione-S-transferase P (GSTP) has been implicated in asthma pathogenesis and regulates the oxidation state of proteins vi...

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Detalles Bibliográficos
Autores principales: van de Wetering, Cheryl, Manuel, Allison M., Sharafi, Mona, Aboushousha, Reem, Qian, Xi, Erickson, Cuixia, MacPherson, Maximilian, Chan, Garrett, Adcock, Ian M., ZounematKermani, Nazanin, Schleich, Florence, Louis, Renaud, Bohrnsen, Eric, D'Alessandro, Angelo, Wouters, Emiel F., Reynaert, Niki L., Li, Jianing, Wolf, C. Roland, Henderson, Colin J., Lundblad, Lennart K.A., Poynter, Matthew E., Dixon, Anne E., Irvin, Charles G., van der Vliet, Albert, van der Velden, Jos L., Janssen-Heininger, Yvonne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502950/
https://www.ncbi.nlm.nih.gov/pubmed/34624602
http://dx.doi.org/10.1016/j.redox.2021.102160

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