Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation

The incidence of cardiovascular disease (CVD) is higher in cancer survivors than in the general population. Several cancer treatments are recognized as risk factors for CVD, but specific therapies are unavailable. Many cancer treatments activate shared signaling events, which reprogram myeloid cells...

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Detalles Bibliográficos
Autores principales: Kotla, Sivareddy, Zhang, Aijun, Imanishi, Masaki, Ko, Kyung Ae, Lin, Steven H., Gi, Young Jin, Moczygemba, Margie, Isgandarova, Sevinj, Schadler, Keri L., Chung, Caroline, Milgrom, Sarah A., Banchs, Jose, Yusuf, Syed Wamique, Amaya, Diana N., Guo, Huifang, Thomas, Tamlyn N., Shen, Ying H., Deswal, Anita, Herrmann, Joerg, Kleinerman, Eugenie S., Entman, Mark L., Cooke, John P., Schifitto, Giovanni, Maggirwar, Sanjay B., McBeath, Elena, Gupte, Anisha A., Krishnan, Sunil, Patel, Zarana S., Yoon, Yisang, Burks, Jared K., Fujiwara, Keigi, Brookes, Paul S., Le, Nhat-Tu, Hamilton, Dale J., Abe, Jun-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502954/
https://www.ncbi.nlm.nih.gov/pubmed/34619528
http://dx.doi.org/10.1016/j.redox.2021.102132

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