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Roles of Non-coding RNAs and Angiogenesis in Glioblastoma

One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (...

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Autores principales: Balandeh, Ebrahim, Mohammadshafie, Kimia, Mahmoudi, Yaser, Hossein Pourhanifeh, Mohammad, Rajabi, Ali, Bahabadi, Zahra Razaghi, Mohammadi, Amir Hossein, Rahimian, Neda, Hamblin, Michael R., Mirzaei, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502969/
https://www.ncbi.nlm.nih.gov/pubmed/34646821
http://dx.doi.org/10.3389/fcell.2021.716462
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author Balandeh, Ebrahim
Mohammadshafie, Kimia
Mahmoudi, Yaser
Hossein Pourhanifeh, Mohammad
Rajabi, Ali
Bahabadi, Zahra Razaghi
Mohammadi, Amir Hossein
Rahimian, Neda
Hamblin, Michael R.
Mirzaei, Hamed
author_facet Balandeh, Ebrahim
Mohammadshafie, Kimia
Mahmoudi, Yaser
Hossein Pourhanifeh, Mohammad
Rajabi, Ali
Bahabadi, Zahra Razaghi
Mohammadi, Amir Hossein
Rahimian, Neda
Hamblin, Michael R.
Mirzaei, Hamed
author_sort Balandeh, Ebrahim
collection PubMed
description One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways.
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spelling pubmed-85029692021-10-12 Roles of Non-coding RNAs and Angiogenesis in Glioblastoma Balandeh, Ebrahim Mohammadshafie, Kimia Mahmoudi, Yaser Hossein Pourhanifeh, Mohammad Rajabi, Ali Bahabadi, Zahra Razaghi Mohammadi, Amir Hossein Rahimian, Neda Hamblin, Michael R. Mirzaei, Hamed Front Cell Dev Biol Cell and Developmental Biology One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways. Frontiers Media S.A. 2021-09-27 /pmc/articles/PMC8502969/ /pubmed/34646821 http://dx.doi.org/10.3389/fcell.2021.716462 Text en Copyright © 2021 Balandeh, Mohammadshafie, Mahmoudi, Hossein Pourhanifeh, Rajabi, Bahabadi, Mohammadi, Rahimian, Hamblin and Mirzaei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Balandeh, Ebrahim
Mohammadshafie, Kimia
Mahmoudi, Yaser
Hossein Pourhanifeh, Mohammad
Rajabi, Ali
Bahabadi, Zahra Razaghi
Mohammadi, Amir Hossein
Rahimian, Neda
Hamblin, Michael R.
Mirzaei, Hamed
Roles of Non-coding RNAs and Angiogenesis in Glioblastoma
title Roles of Non-coding RNAs and Angiogenesis in Glioblastoma
title_full Roles of Non-coding RNAs and Angiogenesis in Glioblastoma
title_fullStr Roles of Non-coding RNAs and Angiogenesis in Glioblastoma
title_full_unstemmed Roles of Non-coding RNAs and Angiogenesis in Glioblastoma
title_short Roles of Non-coding RNAs and Angiogenesis in Glioblastoma
title_sort roles of non-coding rnas and angiogenesis in glioblastoma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502969/
https://www.ncbi.nlm.nih.gov/pubmed/34646821
http://dx.doi.org/10.3389/fcell.2021.716462
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