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Roles of Non-coding RNAs and Angiogenesis in Glioblastoma
One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502969/ https://www.ncbi.nlm.nih.gov/pubmed/34646821 http://dx.doi.org/10.3389/fcell.2021.716462 |
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author | Balandeh, Ebrahim Mohammadshafie, Kimia Mahmoudi, Yaser Hossein Pourhanifeh, Mohammad Rajabi, Ali Bahabadi, Zahra Razaghi Mohammadi, Amir Hossein Rahimian, Neda Hamblin, Michael R. Mirzaei, Hamed |
author_facet | Balandeh, Ebrahim Mohammadshafie, Kimia Mahmoudi, Yaser Hossein Pourhanifeh, Mohammad Rajabi, Ali Bahabadi, Zahra Razaghi Mohammadi, Amir Hossein Rahimian, Neda Hamblin, Michael R. Mirzaei, Hamed |
author_sort | Balandeh, Ebrahim |
collection | PubMed |
description | One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways. |
format | Online Article Text |
id | pubmed-8502969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85029692021-10-12 Roles of Non-coding RNAs and Angiogenesis in Glioblastoma Balandeh, Ebrahim Mohammadshafie, Kimia Mahmoudi, Yaser Hossein Pourhanifeh, Mohammad Rajabi, Ali Bahabadi, Zahra Razaghi Mohammadi, Amir Hossein Rahimian, Neda Hamblin, Michael R. Mirzaei, Hamed Front Cell Dev Biol Cell and Developmental Biology One of the significant hallmarks of cancer is angiogenesis. It has a crucial function in tumor development and metastasis. Thus, angiogenesis has become one of the most exciting targets for drug development in cancer treatment. Here we discuss the regulatory effects on angiogenesis in glioblastoma (GBM) of non-coding RNAs (ncRNAs), including long ncRNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). These ncRNAs may function in trans or cis forms and modify gene transcription by various mechanisms, including epigenetics. NcRNAs may also serve as crucial regulators of angiogenesis-inducing molecules. These molecules include, metalloproteinases, cytokines, several growth factors (platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, hypoxia-inducible factor-1, and epidermal growth factor), phosphoinositide 3-kinase, mitogen-activated protein kinase, and transforming growth factor signaling pathways. Frontiers Media S.A. 2021-09-27 /pmc/articles/PMC8502969/ /pubmed/34646821 http://dx.doi.org/10.3389/fcell.2021.716462 Text en Copyright © 2021 Balandeh, Mohammadshafie, Mahmoudi, Hossein Pourhanifeh, Rajabi, Bahabadi, Mohammadi, Rahimian, Hamblin and Mirzaei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Balandeh, Ebrahim Mohammadshafie, Kimia Mahmoudi, Yaser Hossein Pourhanifeh, Mohammad Rajabi, Ali Bahabadi, Zahra Razaghi Mohammadi, Amir Hossein Rahimian, Neda Hamblin, Michael R. Mirzaei, Hamed Roles of Non-coding RNAs and Angiogenesis in Glioblastoma |
title | Roles of Non-coding RNAs and Angiogenesis in Glioblastoma |
title_full | Roles of Non-coding RNAs and Angiogenesis in Glioblastoma |
title_fullStr | Roles of Non-coding RNAs and Angiogenesis in Glioblastoma |
title_full_unstemmed | Roles of Non-coding RNAs and Angiogenesis in Glioblastoma |
title_short | Roles of Non-coding RNAs and Angiogenesis in Glioblastoma |
title_sort | roles of non-coding rnas and angiogenesis in glioblastoma |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502969/ https://www.ncbi.nlm.nih.gov/pubmed/34646821 http://dx.doi.org/10.3389/fcell.2021.716462 |
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