Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires

Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mAb development. Here, we present position-specific...

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Detalles Bibliográficos
Autores principales: Petersen, Brian M., Ulmer, Sophia A., Rhodes, Emily R., Gutierrez-Gonzalez, Matias F., Dekosky, Brandon J., Sprenger, Kayla G., Whitehead, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503325/
https://www.ncbi.nlm.nih.gov/pubmed/34646268
http://dx.doi.org/10.3389/fimmu.2021.728694

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