Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the β3–β4 loop to favor a low-affinity drug-binding state

Resistance to the extended-spectrum cephalosporin ceftriaxone in the pathogenic bacteria Neisseria gonorrhoeae is conferred by mutations in penicillin-binding protein 2 (PBP2), the lethal target of the antibiotic, but how these mutations exert their effect at the molecular level is unclear. Using so...

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Detalles Bibliográficos
Autores principales: Fenton, Benjamin A., Tomberg, Joshua, Sciandra, Carly A., Nicholas, Robert A., Davies, Christopher, Zhou, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503634/
https://www.ncbi.nlm.nih.gov/pubmed/34529975
http://dx.doi.org/10.1016/j.jbc.2021.101188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503634/
https://www.ncbi.nlm.nih.gov/pubmed/34529975
http://dx.doi.org/10.1016/j.jbc.2021.101188

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