Cargando…
d-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases
Case series Patients: Female, 19-year-old • Female, 23-year-old Final Diagnosis: Anovulation Symptoms: Oligomenorrhea Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology OBJECTIVE: Unknown etiology BACKGROUND: Anovulation consists in the lack of oocyte release during the menstru...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503791/ https://www.ncbi.nlm.nih.gov/pubmed/34615846 http://dx.doi.org/10.12659/AJCR.932722 |
_version_ | 1784581202812862464 |
---|---|
author | Espinola, Maria Salomé Bezerra Laganà, Antonio Simone Bilotta, Gabriele Gullo, Giuseppe Aragona, Cesare Unfer, Vittorio |
author_facet | Espinola, Maria Salomé Bezerra Laganà, Antonio Simone Bilotta, Gabriele Gullo, Giuseppe Aragona, Cesare Unfer, Vittorio |
author_sort | Espinola, Maria Salomé Bezerra |
collection | PubMed |
description | Case series Patients: Female, 19-year-old • Female, 23-year-old Final Diagnosis: Anovulation Symptoms: Oligomenorrhea Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology OBJECTIVE: Unknown etiology BACKGROUND: Anovulation consists in the lack of oocyte release during the menstrual cycle, leading to an irregular menstrual cycle. Untreated chronic anovulation is one of the major causes of female infertility and can induce hypoestrogenism. Different etiological factors can contribute to anovulation; therefore, the clinical approaches to manage this condition should take into account the specific patient characteristics. Oral ovulation-inducing agents are first-line treatments for most anovulatory patients. Drugs used include selective estrogen receptor modulators (SERMs) such as clomiphene citrate and aromatase inhibitors (AIs) such as letrozole. The latter, in particular, halts the estrogen biosynthesis by blocking the activity of steroidogenic enzyme aromatase, which catalyzes the conversion of androgens to estrogens. Similarly, d-chiro-inositol (DCI) modulates the activity of aromatase by reducing the corresponding gene expression, and DCI supplementation was successfully used to induce ovulation in anovulatory PCOS patients. Here, we report the use of DCI to induce ovulation in non-PCOS anovulatory oligomenorrheic women. CASE REPORTS: Two young non-PCOS anovulatory oligomenorrheic women received treatment with high-dose (1200 mg) DCI for 6 weeks. Based on an initial evaluation, both patients had normal hormone levels and were non-insulin-resistant. Ovulation assessment was based on the increment of progesterone and LH levels, as well as on the endometrial thickening. Also, the treatment with DCI resulted in a reduction of testosterone levels relative to baseline values. CONCLUSIONS: After the 6-week treatment with 1200 mg DCI, ovulation was restored in both women, as confirmed by increased progesterone and LH and endometrial thickening. |
format | Online Article Text |
id | pubmed-8503791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85037912021-11-02 d-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases Espinola, Maria Salomé Bezerra Laganà, Antonio Simone Bilotta, Gabriele Gullo, Giuseppe Aragona, Cesare Unfer, Vittorio Am J Case Rep Articles Case series Patients: Female, 19-year-old • Female, 23-year-old Final Diagnosis: Anovulation Symptoms: Oligomenorrhea Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology OBJECTIVE: Unknown etiology BACKGROUND: Anovulation consists in the lack of oocyte release during the menstrual cycle, leading to an irregular menstrual cycle. Untreated chronic anovulation is one of the major causes of female infertility and can induce hypoestrogenism. Different etiological factors can contribute to anovulation; therefore, the clinical approaches to manage this condition should take into account the specific patient characteristics. Oral ovulation-inducing agents are first-line treatments for most anovulatory patients. Drugs used include selective estrogen receptor modulators (SERMs) such as clomiphene citrate and aromatase inhibitors (AIs) such as letrozole. The latter, in particular, halts the estrogen biosynthesis by blocking the activity of steroidogenic enzyme aromatase, which catalyzes the conversion of androgens to estrogens. Similarly, d-chiro-inositol (DCI) modulates the activity of aromatase by reducing the corresponding gene expression, and DCI supplementation was successfully used to induce ovulation in anovulatory PCOS patients. Here, we report the use of DCI to induce ovulation in non-PCOS anovulatory oligomenorrheic women. CASE REPORTS: Two young non-PCOS anovulatory oligomenorrheic women received treatment with high-dose (1200 mg) DCI for 6 weeks. Based on an initial evaluation, both patients had normal hormone levels and were non-insulin-resistant. Ovulation assessment was based on the increment of progesterone and LH levels, as well as on the endometrial thickening. Also, the treatment with DCI resulted in a reduction of testosterone levels relative to baseline values. CONCLUSIONS: After the 6-week treatment with 1200 mg DCI, ovulation was restored in both women, as confirmed by increased progesterone and LH and endometrial thickening. International Scientific Literature, Inc. 2021-10-07 /pmc/articles/PMC8503791/ /pubmed/34615846 http://dx.doi.org/10.12659/AJCR.932722 Text en © Am J Case Rep, 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Espinola, Maria Salomé Bezerra Laganà, Antonio Simone Bilotta, Gabriele Gullo, Giuseppe Aragona, Cesare Unfer, Vittorio d-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases |
title | d-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases |
title_full | d-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases |
title_fullStr | d-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases |
title_full_unstemmed | d-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases |
title_short | d-chiro-inositol Induces Ovulation in Non-Polycystic Ovary Syndrome (PCOS), Non-Insulin-Resistant Young Women, Likely by Modulating Aromatase Expression: A Report of 2 Cases |
title_sort | d-chiro-inositol induces ovulation in non-polycystic ovary syndrome (pcos), non-insulin-resistant young women, likely by modulating aromatase expression: a report of 2 cases |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503791/ https://www.ncbi.nlm.nih.gov/pubmed/34615846 http://dx.doi.org/10.12659/AJCR.932722 |
work_keys_str_mv | AT espinolamariasalomebezerra dchiroinositolinducesovulationinnonpolycysticovarysyndromepcosnoninsulinresistantyoungwomenlikelybymodulatingaromataseexpressionareportof2cases AT laganaantoniosimone dchiroinositolinducesovulationinnonpolycysticovarysyndromepcosnoninsulinresistantyoungwomenlikelybymodulatingaromataseexpressionareportof2cases AT bilottagabriele dchiroinositolinducesovulationinnonpolycysticovarysyndromepcosnoninsulinresistantyoungwomenlikelybymodulatingaromataseexpressionareportof2cases AT gullogiuseppe dchiroinositolinducesovulationinnonpolycysticovarysyndromepcosnoninsulinresistantyoungwomenlikelybymodulatingaromataseexpressionareportof2cases AT aragonacesare dchiroinositolinducesovulationinnonpolycysticovarysyndromepcosnoninsulinresistantyoungwomenlikelybymodulatingaromataseexpressionareportof2cases AT unfervittorio dchiroinositolinducesovulationinnonpolycysticovarysyndromepcosnoninsulinresistantyoungwomenlikelybymodulatingaromataseexpressionareportof2cases |