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Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer
As key regulators of apoptosis, BAD and defender against apoptotic cell death 1 (DAD1) are associated with cancer initiation and progression. Multiple studies have demonstrated that BAD and DAD1 serve critical roles in several types of cancer and perform various functions, such as participating in c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503815/ https://www.ncbi.nlm.nih.gov/pubmed/34671425 http://dx.doi.org/10.3892/ol.2021.13072 |
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author | Luo, Yulou Wu, You Huang, Hai Yi, Na Chen, Yan |
author_facet | Luo, Yulou Wu, You Huang, Hai Yi, Na Chen, Yan |
author_sort | Luo, Yulou |
collection | PubMed |
description | As key regulators of apoptosis, BAD and defender against apoptotic cell death 1 (DAD1) are associated with cancer initiation and progression. Multiple studies have demonstrated that BAD and DAD1 serve critical roles in several types of cancer and perform various functions, such as participating in cellular apoptosis, invasion and chemosensitivity, as well as their role in diagnostic/prognostic judgement, etc. Investigating the detailed mechanisms of the cancerous effects of the two proteins will contribute to enriching the options for targeted therapy, and may improve clinical treatment of cancer. The present review summarizes research advances regarding the associations of BAD and DAD1 with cancer, and a hypothesis on the feasible relationship and interaction mechanism between the two proteins is proposed. Furthermore, the present review highlights the potential of the two proteins as therapeutic targets and valuable diagnostic and prognostic biomarkers. |
format | Online Article Text |
id | pubmed-8503815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-85038152021-10-19 Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer Luo, Yulou Wu, You Huang, Hai Yi, Na Chen, Yan Oncol Lett Review As key regulators of apoptosis, BAD and defender against apoptotic cell death 1 (DAD1) are associated with cancer initiation and progression. Multiple studies have demonstrated that BAD and DAD1 serve critical roles in several types of cancer and perform various functions, such as participating in cellular apoptosis, invasion and chemosensitivity, as well as their role in diagnostic/prognostic judgement, etc. Investigating the detailed mechanisms of the cancerous effects of the two proteins will contribute to enriching the options for targeted therapy, and may improve clinical treatment of cancer. The present review summarizes research advances regarding the associations of BAD and DAD1 with cancer, and a hypothesis on the feasible relationship and interaction mechanism between the two proteins is proposed. Furthermore, the present review highlights the potential of the two proteins as therapeutic targets and valuable diagnostic and prognostic biomarkers. D.A. Spandidos 2021-12 2021-09-28 /pmc/articles/PMC8503815/ /pubmed/34671425 http://dx.doi.org/10.3892/ol.2021.13072 Text en Copyright: © Luo et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Luo, Yulou Wu, You Huang, Hai Yi, Na Chen, Yan Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer |
title | Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer |
title_full | Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer |
title_fullStr | Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer |
title_full_unstemmed | Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer |
title_short | Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer |
title_sort | emerging role of bad and dad1 as potential targets and biomarkers in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503815/ https://www.ncbi.nlm.nih.gov/pubmed/34671425 http://dx.doi.org/10.3892/ol.2021.13072 |
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