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Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation

To maintain secretory pathway fidelity, misfolded proteins are commonly retained in the endoplasmic reticulum (ER) and selected for ER-associated degradation (ERAD). Soluble misfolded proteins use ER chaperones for retention, but the machinery that restricts aberrant membrane proteins to the ER is u...

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Detalles Bibliográficos
Autores principales:	Sun, Zhihao, Guerriero, Christopher J., Brodsky, Jeffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503845/ https://www.ncbi.nlm.nih.gov/pubmed/34551305 http://dx.doi.org/10.1016/j.celrep.2021.109717

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