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The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin
Schizophrenia is often a severe and debilitating mental illness, frequently associated with impairments in social cognition that hinder individuals' abilities to relate to others and integrate effectively in society. Oxytocin has emerged as a putative therapeutic agent for treating social defic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503903/ https://www.ncbi.nlm.nih.gov/pubmed/34660212 http://dx.doi.org/10.1016/j.scog.2021.100221 |
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author | Wigton, Rebekah Tracy, Derek K. Verneuil, Tess M. Johns, Michaela White, Thomas Michalopoulou, Panayiota G. Averbeck, Bruno Shergill, Sukhwinder |
author_facet | Wigton, Rebekah Tracy, Derek K. Verneuil, Tess M. Johns, Michaela White, Thomas Michalopoulou, Panayiota G. Averbeck, Bruno Shergill, Sukhwinder |
author_sort | Wigton, Rebekah |
collection | PubMed |
description | Schizophrenia is often a severe and debilitating mental illness, frequently associated with impairments in social cognition that hinder individuals' abilities to relate to others and integrate effectively in society. Oxytocin has emerged as a putative therapeutic agent for treating social deficits in schizophrenia, but the mode of action remains unclear. This placebo-controlled crossover study aimed to elucidate the neural underpinnings of oxytocin administration in patients with schizophrenia. 20 patients with schizophrenia were examined using functional magnetic resonance imaging under oxytocin (40 IU) or placebo nasal spray. Participants performed a stochastically rewarded decision-making task that incorporated elements of social valence provided by different facial expressions, i.e. happy, angry and neutral. Oxytocin attenuated the normal bias in selecting the happy face accompanied by reduced activation in a network of brain regions that support mentalising, processing of facial emotion, salience, aversion, uncertainty and ambiguity in social stimuli, including amygdala, temporo-parietal junction, posterior cingulate cortex, precuneus and insula. These pro-social effects may contribute to the facilitation of social engagement and social interactions in patients with schizophrenia and warrant further investigation in future clinical trials for social cognitive impairments in schizophrenia. |
format | Online Article Text |
id | pubmed-8503903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85039032021-10-15 The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin Wigton, Rebekah Tracy, Derek K. Verneuil, Tess M. Johns, Michaela White, Thomas Michalopoulou, Panayiota G. Averbeck, Bruno Shergill, Sukhwinder Schizophr Res Cogn Research Paper Schizophrenia is often a severe and debilitating mental illness, frequently associated with impairments in social cognition that hinder individuals' abilities to relate to others and integrate effectively in society. Oxytocin has emerged as a putative therapeutic agent for treating social deficits in schizophrenia, but the mode of action remains unclear. This placebo-controlled crossover study aimed to elucidate the neural underpinnings of oxytocin administration in patients with schizophrenia. 20 patients with schizophrenia were examined using functional magnetic resonance imaging under oxytocin (40 IU) or placebo nasal spray. Participants performed a stochastically rewarded decision-making task that incorporated elements of social valence provided by different facial expressions, i.e. happy, angry and neutral. Oxytocin attenuated the normal bias in selecting the happy face accompanied by reduced activation in a network of brain regions that support mentalising, processing of facial emotion, salience, aversion, uncertainty and ambiguity in social stimuli, including amygdala, temporo-parietal junction, posterior cingulate cortex, precuneus and insula. These pro-social effects may contribute to the facilitation of social engagement and social interactions in patients with schizophrenia and warrant further investigation in future clinical trials for social cognitive impairments in schizophrenia. Elsevier 2021-10-09 /pmc/articles/PMC8503903/ /pubmed/34660212 http://dx.doi.org/10.1016/j.scog.2021.100221 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Wigton, Rebekah Tracy, Derek K. Verneuil, Tess M. Johns, Michaela White, Thomas Michalopoulou, Panayiota G. Averbeck, Bruno Shergill, Sukhwinder The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin |
title | The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin |
title_full | The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin |
title_fullStr | The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin |
title_full_unstemmed | The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin |
title_short | The importance of pro-social processing, and ameliorating dysfunction in schizophrenia. An FMRI study of oxytocin |
title_sort | importance of pro-social processing, and ameliorating dysfunction in schizophrenia. an fmri study of oxytocin |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503903/ https://www.ncbi.nlm.nih.gov/pubmed/34660212 http://dx.doi.org/10.1016/j.scog.2021.100221 |
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