Cargando…

组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用

Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis and metastasis of cancer. Protein kinases and...

Descripción completa

Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 中国肺癌杂志编辑部 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503980/
https://www.ncbi.nlm.nih.gov/pubmed/34455734
http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.28
_version_ 1784581236475297792
collection PubMed
description Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis and metastasis of cancer. Protein kinases and phosphatases generally regulate protein phosphorylation levels as a pair of opposite acting enzymes. Protein phosphorylation in eukaryotes occurs mainly in serine, threonine, and tyrosine residues, and their roles in tumorigenesis and development have been extensively studied. But the roles on histidine phosphorylation is less known due to the immature mass spectrometry and enrichment techniques. In recent years, with the rapid development of related technologies and the discovery of new histidine phosphatases, researchers have paid more attention to the roles of histidine phosphorylation in tumors. Therefore, we aim to review the roles of histidine kinases and phosphatases in tumor.
format Online
Article
Text
id pubmed-8503980
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher 中国肺癌杂志编辑部
record_format MEDLINE/PubMed
spelling pubmed-85039802021-10-22 组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用 Zhongguo Fei Ai Za Zhi 综述 Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis and metastasis of cancer. Protein kinases and phosphatases generally regulate protein phosphorylation levels as a pair of opposite acting enzymes. Protein phosphorylation in eukaryotes occurs mainly in serine, threonine, and tyrosine residues, and their roles in tumorigenesis and development have been extensively studied. But the roles on histidine phosphorylation is less known due to the immature mass spectrometry and enrichment techniques. In recent years, with the rapid development of related technologies and the discovery of new histidine phosphatases, researchers have paid more attention to the roles of histidine phosphorylation in tumors. Therefore, we aim to review the roles of histidine kinases and phosphatases in tumor. 中国肺癌杂志编辑部 2021-09-20 /pmc/articles/PMC8503980/ /pubmed/34455734 http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.28 Text en 版权所有©《中国肺癌杂志》编辑部2021 https://creativecommons.org/licenses/by/3.0/This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/.
spellingShingle 综述
组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用
title 组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用
title_full 组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用
title_fullStr 组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用
title_full_unstemmed 组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用
title_short 组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用
title_sort 组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用
topic 综述
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503980/
https://www.ncbi.nlm.nih.gov/pubmed/34455734
http://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.28
work_keys_str_mv AT zǔānsuānjīméihézǔānsuānlínsuānméizàizhǒngliúzhōngdezuòyòng
AT zǔānsuānjīméihézǔānsuānlínsuānméizàizhǒngliúzhōngdezuòyòng
AT zǔānsuānjīméihézǔānsuānlínsuānméizàizhǒngliúzhōngdezuòyòng
AT zǔānsuānjīméihézǔānsuānlínsuānméizàizhǒngliúzhōngdezuòyòng