Cargando…

Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension

BACKGROUND: Obesity confers adverse effects to every system in the body including the central nervous system. Obesity is associated with both migraine and idiopathic intracranial hypertension (IIH). The mechanisms underlying the association between obesity and these headache diseases remain unclear....

Descripción completa

Detalles Bibliográficos
Autores principales: Westgate, Connar Stanley James, Israelsen, Ida Marchen Egerod, Jensen, Rigmor Højland, Eftekhari, Sajedeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504002/
https://www.ncbi.nlm.nih.gov/pubmed/34629054
http://dx.doi.org/10.1186/s10194-021-01337-0
_version_ 1784581242403946496
author Westgate, Connar Stanley James
Israelsen, Ida Marchen Egerod
Jensen, Rigmor Højland
Eftekhari, Sajedeh
author_facet Westgate, Connar Stanley James
Israelsen, Ida Marchen Egerod
Jensen, Rigmor Højland
Eftekhari, Sajedeh
author_sort Westgate, Connar Stanley James
collection PubMed
description BACKGROUND: Obesity confers adverse effects to every system in the body including the central nervous system. Obesity is associated with both migraine and idiopathic intracranial hypertension (IIH). The mechanisms underlying the association between obesity and these headache diseases remain unclear. METHODS: We conducted a narrative review of the evidence in both humans and rodents, for the putative mechanisms underlying the link between obesity, migraine and IIH. RESULTS: Truncal adiposity, a key feature of obesity, is associated with increased migraine morbidity and disability through increased headache severity, frequency and more severe cutaneous allodynia. Obesity may also increase intracranial pressure and could contribute to headache morbidity in migraine and be causative in IIH headache. Weight loss can improve both migraine and IIH headache. Preclinical research highlights that obesity increases the sensitivity of the trigeminovascular system to noxious stimuli including inflammatory stimuli, but the underlying molecular mechanisms remain unelucidated. CONCLUSIONS: This review highlights that at the epidemiological and clinical level, obesity increases morbidity in migraine and IIH headache, where weight loss can improve headache morbidity. However, further research is required to understand the molecular underpinnings of obesity related headache in order to generate novel treatments.
format Online
Article
Text
id pubmed-8504002
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Milan
record_format MEDLINE/PubMed
spelling pubmed-85040022021-10-20 Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension Westgate, Connar Stanley James Israelsen, Ida Marchen Egerod Jensen, Rigmor Højland Eftekhari, Sajedeh J Headache Pain Review Article BACKGROUND: Obesity confers adverse effects to every system in the body including the central nervous system. Obesity is associated with both migraine and idiopathic intracranial hypertension (IIH). The mechanisms underlying the association between obesity and these headache diseases remain unclear. METHODS: We conducted a narrative review of the evidence in both humans and rodents, for the putative mechanisms underlying the link between obesity, migraine and IIH. RESULTS: Truncal adiposity, a key feature of obesity, is associated with increased migraine morbidity and disability through increased headache severity, frequency and more severe cutaneous allodynia. Obesity may also increase intracranial pressure and could contribute to headache morbidity in migraine and be causative in IIH headache. Weight loss can improve both migraine and IIH headache. Preclinical research highlights that obesity increases the sensitivity of the trigeminovascular system to noxious stimuli including inflammatory stimuli, but the underlying molecular mechanisms remain unelucidated. CONCLUSIONS: This review highlights that at the epidemiological and clinical level, obesity increases morbidity in migraine and IIH headache, where weight loss can improve headache morbidity. However, further research is required to understand the molecular underpinnings of obesity related headache in order to generate novel treatments. Springer Milan 2021-10-10 /pmc/articles/PMC8504002/ /pubmed/34629054 http://dx.doi.org/10.1186/s10194-021-01337-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review Article
Westgate, Connar Stanley James
Israelsen, Ida Marchen Egerod
Jensen, Rigmor Højland
Eftekhari, Sajedeh
Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension
title Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension
title_full Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension
title_fullStr Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension
title_full_unstemmed Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension
title_short Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension
title_sort understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504002/
https://www.ncbi.nlm.nih.gov/pubmed/34629054
http://dx.doi.org/10.1186/s10194-021-01337-0
work_keys_str_mv AT westgateconnarstanleyjames understandingthelinkbetweenobesityandheadachewithfocusonmigraineandidiopathicintracranialhypertension
AT israelsenidamarchenegerod understandingthelinkbetweenobesityandheadachewithfocusonmigraineandidiopathicintracranialhypertension
AT jensenrigmorhøjland understandingthelinkbetweenobesityandheadachewithfocusonmigraineandidiopathicintracranialhypertension
AT eftekharisajedeh understandingthelinkbetweenobesityandheadachewithfocusonmigraineandidiopathicintracranialhypertension