Rationale and design of the Diet Restriction and Exercise-induced Adaptations in Metastatic breast cancer (DREAM) study: a 2-arm, parallel-group, phase II, randomized control trial of a short-term, calorie-restricted, and ketogenic diet plus exercise during intravenous chemotherapy versus usual care

BACKGROUND: An underlying cause of solid tumor resistance to chemotherapy treatment is diminished tumor blood supply, which leads to a hypoxic microenvironment, dependence on anaerobic energy metabolism, and impaired delivery of intravenous treatments. Preclinical data suggest that dietary strategie...

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Detalles Bibliográficos
Autores principales: Kirkham, Amy A., King, Karen, Joy, Anil A., Pelletier, André B., Mackey, John R., Young, Kelvin, Zhu, Xiaofu, Meza-Junco, Judith, Basi, Sanraj K., Hiller, Julie Price, Brkin, Tina, Michalowski, Bonnie, Pituskin, Edith, Paterson, D. Ian, Courneya, Kerry S., Thompson, Richard B., Prado, Carla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504029/
https://www.ncbi.nlm.nih.gov/pubmed/34629067
http://dx.doi.org/10.1186/s12885-021-08808-2

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