Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus

BACKGROUND: Genome-wide association studies (GWASs) have identified thousands of variants associated with asthma and other complex diseases. However, the functional effects of most of these variants are unknown. Moreover, GWASs do not provide context-specific information on cell types or environment...

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Detalles Bibliográficos
Autores principales: Soliai, Marcus M., Kato, Atsushi, Helling, Britney A., Stanhope, Catherine T., Norton, James E., Naughton, Katherine A., Klinger, Aiko I., Thompson, Emma E., Clay, Selene M., Kim, Soyeon, Celedón, Juan C., Gern, James E., Jackson, Daniel J., Altman, Matthew C., Kern, Robert C., Tan, Bruce K., Schleimer, Robert P., Nicolae, Dan L., Pinto, Jayant M., Ober, Carole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504130/
https://www.ncbi.nlm.nih.gov/pubmed/34629083
http://dx.doi.org/10.1186/s13073-021-00967-y

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