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Single-particle cryo-EM reveals conformational variability of the oligomeric VCC β-barrel pore in a lipid bilayer

Vibrio cholerae cytolysin (VCC) is a water-soluble, membrane-damaging, pore-forming toxin (PFT) secreted by pathogenic V. cholerae, which causes eukaryotic cell death by altering the plasma membrane permeability. VCC self-assembles on the cell surface and undergoes a dramatic conformational change f...

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Detalles Bibliográficos
Autores principales:	Sengupta, Nayanika, Mondal, Anish Kumar, Mishra, Suman, Chattopadhyay, Kausik, Dutta, Somnath
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504180/ https://www.ncbi.nlm.nih.gov/pubmed/34617964 http://dx.doi.org/10.1083/jcb.202102035

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