Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe

Glioblastoma ranks among the most lethal of primary brain malignancies, with glioblastoma stem cells (GSCs) at the apex of tumor cellular hierarchies. Here, to discover novel therapeutic GSC targets, we interrogated gene expression profiles from GSCs, differentiated glioblastoma cells (DGCs), and ne...

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Detalles Bibliográficos
Autores principales: Zhang, Guoxin, Dong, Zhen, Gimple, Ryan C., Wolin, Arthur, Wu, Qiulian, Qiu, Zhixin, Wood, Lisa M., Shen, Jia Z., Jiang, Li, Zhao, Linjie, Lv, Deguan, Prager, Briana C., Kim, Leo J.Y., Wang, Xiuxing, Zhang, Lingdi, Anderson, Ryan L., Moore, Jeffrey K., Bao, Shideng, Keller, Thomas H., Lin, Grace, Kang, Congbao, Hamerlik, Petra, Zhao, Rui, Ford, Heide L., Rich, Jeremy N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504185/
https://www.ncbi.nlm.nih.gov/pubmed/34617969
http://dx.doi.org/10.1084/jem.20202669

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