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Diagnostic and Therapeutic Potential of Extracellular Vesicles

Extracellular vesicles (EVs) are naturally phospholipid enclosed nanovesicles released by many cells in the body. They are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules. They interact with target organs and bind to the receptors. The...

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Detalles Bibliográficos
Autores principales: Kodam, Sai Priyanka, Ullah, Mujib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504225/
https://www.ncbi.nlm.nih.gov/pubmed/34632862
http://dx.doi.org/10.1177/15330338211041203
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author Kodam, Sai Priyanka
Ullah, Mujib
author_facet Kodam, Sai Priyanka
Ullah, Mujib
author_sort Kodam, Sai Priyanka
collection PubMed
description Extracellular vesicles (EVs) are naturally phospholipid enclosed nanovesicles released by many cells in the body. They are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules. They interact with target organs and bind to the receptors. Their target specificity is important to use EVs as noninvasive diagnostic and prognostic tools. EVs play a vital role in normal physiology and cellular communication. They are known to protect their cargo from degradation, which makes them important drug carriers for targeted drug delivery. Using EVs with markers and tracking their path in systemic circulation can be revolutionary in using them as diagnostic tools. We will discuss the scope of this in this paper. Although there are limitations in EVs isolation and storage, their high biocompatibility will fuel more innovations to overcome these challenges.
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spelling pubmed-85042252021-10-12 Diagnostic and Therapeutic Potential of Extracellular Vesicles Kodam, Sai Priyanka Ullah, Mujib Technol Cancer Res Treat Review Extracellular vesicles (EVs) are naturally phospholipid enclosed nanovesicles released by many cells in the body. They are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules. They interact with target organs and bind to the receptors. Their target specificity is important to use EVs as noninvasive diagnostic and prognostic tools. EVs play a vital role in normal physiology and cellular communication. They are known to protect their cargo from degradation, which makes them important drug carriers for targeted drug delivery. Using EVs with markers and tracking their path in systemic circulation can be revolutionary in using them as diagnostic tools. We will discuss the scope of this in this paper. Although there are limitations in EVs isolation and storage, their high biocompatibility will fuel more innovations to overcome these challenges. SAGE Publications 2021-10-09 /pmc/articles/PMC8504225/ /pubmed/34632862 http://dx.doi.org/10.1177/15330338211041203 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Kodam, Sai Priyanka
Ullah, Mujib
Diagnostic and Therapeutic Potential of Extracellular Vesicles
title Diagnostic and Therapeutic Potential of Extracellular Vesicles
title_full Diagnostic and Therapeutic Potential of Extracellular Vesicles
title_fullStr Diagnostic and Therapeutic Potential of Extracellular Vesicles
title_full_unstemmed Diagnostic and Therapeutic Potential of Extracellular Vesicles
title_short Diagnostic and Therapeutic Potential of Extracellular Vesicles
title_sort diagnostic and therapeutic potential of extracellular vesicles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504225/
https://www.ncbi.nlm.nih.gov/pubmed/34632862
http://dx.doi.org/10.1177/15330338211041203
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