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The Crossroads of Glycoscience, Infection, and Immunology

Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology. These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that oc...

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Autores principales: McKitrick, Tanya R., Ackerman, Margaret E., Anthony, Robert M., Bennett, Clay S., Demetriou, Michael, Hudalla, Gregory A., Ribbeck, Katharina, Ruhl, Stefan, Woo, Christina M., Yang, Loretta, Zost, Seth J., Schnaar, Ronald L., Doering, Tamara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504252/
https://www.ncbi.nlm.nih.gov/pubmed/34646251
http://dx.doi.org/10.3389/fmicb.2021.731008
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author McKitrick, Tanya R.
Ackerman, Margaret E.
Anthony, Robert M.
Bennett, Clay S.
Demetriou, Michael
Hudalla, Gregory A.
Ribbeck, Katharina
Ruhl, Stefan
Woo, Christina M.
Yang, Loretta
Zost, Seth J.
Schnaar, Ronald L.
Doering, Tamara L.
author_facet McKitrick, Tanya R.
Ackerman, Margaret E.
Anthony, Robert M.
Bennett, Clay S.
Demetriou, Michael
Hudalla, Gregory A.
Ribbeck, Katharina
Ruhl, Stefan
Woo, Christina M.
Yang, Loretta
Zost, Seth J.
Schnaar, Ronald L.
Doering, Tamara L.
author_sort McKitrick, Tanya R.
collection PubMed
description Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology. These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters. Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe. In the context of the host, glycosylation drives cell–cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators. This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020. The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function. Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation.
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spelling pubmed-85042522021-10-12 The Crossroads of Glycoscience, Infection, and Immunology McKitrick, Tanya R. Ackerman, Margaret E. Anthony, Robert M. Bennett, Clay S. Demetriou, Michael Hudalla, Gregory A. Ribbeck, Katharina Ruhl, Stefan Woo, Christina M. Yang, Loretta Zost, Seth J. Schnaar, Ronald L. Doering, Tamara L. Front Microbiol Microbiology Advances in experimental capabilities in the glycosciences offer expanding opportunities for discovery in the broad areas of immunology and microbiology. These two disciplines overlap when microbial infection stimulates host immune responses and glycan structures are central in the processes that occur during all such encounters. Microbial glycans mediate host-pathogen interactions by acting as surface receptors or ligands, functioning as virulence factors, impeding host immune responses, or playing other roles in the struggle between host and microbe. In the context of the host, glycosylation drives cell–cell interactions that initiate and regulate the host response and modulates the effects of antibodies and soluble immune mediators. This perspective reports on a workshop organized jointly by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research in May 2020. The conference addressed the use of emerging glycoscience tools and resources to advance investigation of glycans and their roles in microbe-host interactions, immune-mediated diseases, and immune cell recognition and function. Future discoveries in these areas will increase fundamental scientific understanding and have the potential to improve diagnosis and treatment of infections and immune dysregulation. Frontiers Media S.A. 2021-09-27 /pmc/articles/PMC8504252/ /pubmed/34646251 http://dx.doi.org/10.3389/fmicb.2021.731008 Text en Copyright © 2021 McKitrick, Ackerman, Anthony, Bennett, Demetriou, Hudalla, Ribbeck, Ruhl, Woo, Yang, Zost, Schnaar and Doering. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
McKitrick, Tanya R.
Ackerman, Margaret E.
Anthony, Robert M.
Bennett, Clay S.
Demetriou, Michael
Hudalla, Gregory A.
Ribbeck, Katharina
Ruhl, Stefan
Woo, Christina M.
Yang, Loretta
Zost, Seth J.
Schnaar, Ronald L.
Doering, Tamara L.
The Crossroads of Glycoscience, Infection, and Immunology
title The Crossroads of Glycoscience, Infection, and Immunology
title_full The Crossroads of Glycoscience, Infection, and Immunology
title_fullStr The Crossroads of Glycoscience, Infection, and Immunology
title_full_unstemmed The Crossroads of Glycoscience, Infection, and Immunology
title_short The Crossroads of Glycoscience, Infection, and Immunology
title_sort crossroads of glycoscience, infection, and immunology
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504252/
https://www.ncbi.nlm.nih.gov/pubmed/34646251
http://dx.doi.org/10.3389/fmicb.2021.731008
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