Cargando…

Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88

TLR4 polymorphisms such as Asp299Gly and Thr399Ile related to Gram-negative sepsis have been reported to result in significantly blunted responsiveness to LPS. Our study group previously screened other TLR4 polymorphic variants by checking the NF-κB activation in comparison to wild type (WT) TLR4 in...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yajie, Hu, Yan, Zhou, Yile, Liang, Tao, Tang, Haihong, Ju, Huihui, Shi, Qiqing, Fang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504268/
https://www.ncbi.nlm.nih.gov/pubmed/32513051
http://dx.doi.org/10.1177/1753425920927479