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Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells

In bone tissue engineering, tailored biomaterials mimicking mesenchymal stem cells (MSCs) niche could regulate cell behavior and fate decision. The mechanisms, however, remain obscure. Recently, increasing evidence has shown that non-coding RNAs (ncRNAs) are critical modulators of the mechano-induce...

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Detalles Bibliográficos
Autores principales: Cen, Xiao, Pan, Xuefeng, Zhang, Bo, Huang, Wei, Xiong, Xiner, Huang, Xinqi, Liu, Jun, Zhao, Zhihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504269/
https://www.ncbi.nlm.nih.gov/pubmed/34628953
http://dx.doi.org/10.1177/09636897211051382
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author Cen, Xiao
Pan, Xuefeng
Zhang, Bo
Huang, Wei
Xiong, Xiner
Huang, Xinqi
Liu, Jun
Zhao, Zhihe
author_facet Cen, Xiao
Pan, Xuefeng
Zhang, Bo
Huang, Wei
Xiong, Xiner
Huang, Xinqi
Liu, Jun
Zhao, Zhihe
author_sort Cen, Xiao
collection PubMed
description In bone tissue engineering, tailored biomaterials mimicking mesenchymal stem cells (MSCs) niche could regulate cell behavior and fate decision. The mechanisms, however, remain obscure. Recently, increasing evidence has shown that non-coding RNAs (ncRNAs) are critical modulators of the mechano-induced MSCs’ responses. Mechanosensitive ncRNAs could convert various physical forces into biochemical signals, and orchestrate signaling networks that regulate the osteogenic differentiation of MSCs in their unique microenvironment. In this review, we focus on the mechanosensitive ncRNAs which could interpret mechanical stimuli during the osteogenesis of MSCs, summarize the signaling pathway networks by which these ncRNAs drive MSCs fate, and point out the limitations and the areas waiting for further exploration.
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spelling pubmed-85042692021-10-12 Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells Cen, Xiao Pan, Xuefeng Zhang, Bo Huang, Wei Xiong, Xiner Huang, Xinqi Liu, Jun Zhao, Zhihe Cell Transplant Review (Unsolicited) In bone tissue engineering, tailored biomaterials mimicking mesenchymal stem cells (MSCs) niche could regulate cell behavior and fate decision. The mechanisms, however, remain obscure. Recently, increasing evidence has shown that non-coding RNAs (ncRNAs) are critical modulators of the mechano-induced MSCs’ responses. Mechanosensitive ncRNAs could convert various physical forces into biochemical signals, and orchestrate signaling networks that regulate the osteogenic differentiation of MSCs in their unique microenvironment. In this review, we focus on the mechanosensitive ncRNAs which could interpret mechanical stimuli during the osteogenesis of MSCs, summarize the signaling pathway networks by which these ncRNAs drive MSCs fate, and point out the limitations and the areas waiting for further exploration. SAGE Publications 2021-10-09 /pmc/articles/PMC8504269/ /pubmed/34628953 http://dx.doi.org/10.1177/09636897211051382 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review (Unsolicited)
Cen, Xiao
Pan, Xuefeng
Zhang, Bo
Huang, Wei
Xiong, Xiner
Huang, Xinqi
Liu, Jun
Zhao, Zhihe
Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells
title Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells
title_full Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells
title_fullStr Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells
title_full_unstemmed Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells
title_short Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells
title_sort mechanosensitive non-coding rnas in osteogenesis of mesenchymal stem cells
topic Review (Unsolicited)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504269/
https://www.ncbi.nlm.nih.gov/pubmed/34628953
http://dx.doi.org/10.1177/09636897211051382
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