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Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells
In bone tissue engineering, tailored biomaterials mimicking mesenchymal stem cells (MSCs) niche could regulate cell behavior and fate decision. The mechanisms, however, remain obscure. Recently, increasing evidence has shown that non-coding RNAs (ncRNAs) are critical modulators of the mechano-induce...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504269/ https://www.ncbi.nlm.nih.gov/pubmed/34628953 http://dx.doi.org/10.1177/09636897211051382 |
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author | Cen, Xiao Pan, Xuefeng Zhang, Bo Huang, Wei Xiong, Xiner Huang, Xinqi Liu, Jun Zhao, Zhihe |
author_facet | Cen, Xiao Pan, Xuefeng Zhang, Bo Huang, Wei Xiong, Xiner Huang, Xinqi Liu, Jun Zhao, Zhihe |
author_sort | Cen, Xiao |
collection | PubMed |
description | In bone tissue engineering, tailored biomaterials mimicking mesenchymal stem cells (MSCs) niche could regulate cell behavior and fate decision. The mechanisms, however, remain obscure. Recently, increasing evidence has shown that non-coding RNAs (ncRNAs) are critical modulators of the mechano-induced MSCs’ responses. Mechanosensitive ncRNAs could convert various physical forces into biochemical signals, and orchestrate signaling networks that regulate the osteogenic differentiation of MSCs in their unique microenvironment. In this review, we focus on the mechanosensitive ncRNAs which could interpret mechanical stimuli during the osteogenesis of MSCs, summarize the signaling pathway networks by which these ncRNAs drive MSCs fate, and point out the limitations and the areas waiting for further exploration. |
format | Online Article Text |
id | pubmed-8504269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-85042692021-10-12 Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells Cen, Xiao Pan, Xuefeng Zhang, Bo Huang, Wei Xiong, Xiner Huang, Xinqi Liu, Jun Zhao, Zhihe Cell Transplant Review (Unsolicited) In bone tissue engineering, tailored biomaterials mimicking mesenchymal stem cells (MSCs) niche could regulate cell behavior and fate decision. The mechanisms, however, remain obscure. Recently, increasing evidence has shown that non-coding RNAs (ncRNAs) are critical modulators of the mechano-induced MSCs’ responses. Mechanosensitive ncRNAs could convert various physical forces into biochemical signals, and orchestrate signaling networks that regulate the osteogenic differentiation of MSCs in their unique microenvironment. In this review, we focus on the mechanosensitive ncRNAs which could interpret mechanical stimuli during the osteogenesis of MSCs, summarize the signaling pathway networks by which these ncRNAs drive MSCs fate, and point out the limitations and the areas waiting for further exploration. SAGE Publications 2021-10-09 /pmc/articles/PMC8504269/ /pubmed/34628953 http://dx.doi.org/10.1177/09636897211051382 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review (Unsolicited) Cen, Xiao Pan, Xuefeng Zhang, Bo Huang, Wei Xiong, Xiner Huang, Xinqi Liu, Jun Zhao, Zhihe Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells |
title | Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells |
title_full | Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells |
title_fullStr | Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells |
title_full_unstemmed | Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells |
title_short | Mechanosensitive Non-Coding RNAs in Osteogenesis of Mesenchymal Stem Cells |
title_sort | mechanosensitive non-coding rnas in osteogenesis of mesenchymal stem cells |
topic | Review (Unsolicited) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504269/ https://www.ncbi.nlm.nih.gov/pubmed/34628953 http://dx.doi.org/10.1177/09636897211051382 |
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