Cargando…

Promise of metformin for preventing age-related cognitive dysfunction

The expanded lifespan of people, while a positive advance, has also amplified the prevalence of age-related disorders, which include mild cognitive impairment, dementia, and Alzheimer’s disease. Therefore, competent therapies that could improve the healthspan of people have great significance. Some...

Descripción completa

Detalles Bibliográficos
Autores principales:	Madhu, Leelavathi N., Kodali, Maheedhar, Shetty, Ashok K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504370/ https://www.ncbi.nlm.nih.gov/pubmed/34380878 http://dx.doi.org/10.4103/1673-5374.320971

Ejemplares similares

Emerging Anti-Aging Strategies - Scientific Basis and Efficacy
por: Shetty, Ashok K., et al.
Publicado: (2018)

Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus
por: Kodali, Maheedhar, et al.
Publicado: (2021)

Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease
por: Shetty, Ashok K., et al.
Publicado: (2019)

Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness
por: Attaluri, Sahithi, et al.
Publicado: (2022)

Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation
por: Kodali, Maheedhar, et al.
Publicado: (2015)

Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus
por: Madhu, Leelavathi N., et al.
Publicado: (2021)

Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction—Are We There Yet?
por: Castro, Olagide W., et al.
Publicado: (2017)

Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness
por: Shetty, Ashok K., et al.
Publicado: (2019)

A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling
por: Kodali, Maheedhar, et al.
Publicado: (2023)

Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves
por: Shetty, Ashok K., et al.
Publicado: (2014)

Corrigendum: Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves
por: Shetty, Ashok K., et al.
Publicado: (2014)

Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression
por: Attaluri, Sahithi, et al.
Publicado: (2022)

Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties
por: Upadhya, Raghavendra, et al.
Publicado: (2020)

Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain
por: Kodali, Maheedhar, et al.
Publicado: (2019)

Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice
por: Attaluri, Sahithi, et al.
Publicado: (2023)

Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness
por: Shetty, Geetha A., et al.
Publicado: (2017)

Proficiency of Extracellular Vesicles From hiPSC-Derived Neural Stem Cells in Modulating Proinflammatory Human Microglia: Role of Pentraxin-3 and miRNA-21-5p
por: Upadhya, Raghavendra, et al.
Publicado: (2022)

Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness
por: Hattiangady, Bharathi, et al.
Publicado: (2014)

Resveratrol Treatment after Status Epilepticus Restrains Neurodegeneration and Abnormal Neurogenesis with Suppression of Oxidative Stress and Inflammation
por: Mishra, Vikas, et al.
Publicado: (2015)

Metformin for aging and cancer prevention
por: Anisimov, Vladimir N.
Publicado: (2010)

Gulf war illness-related chemicals increase CD11b/c(+) monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model
por: Petrescu, Anca D., et al.
Publicado: (2018)

Metformin use in pregnancy: promises and uncertainties
por: Lindsay, Robert S., et al.
Publicado: (2017)

Metformin: A promising drug for human cancers
por: Wu, Hongnian, et al.
Publicado: (2022)

A Clinical Perspective of the Multifaceted Mechanism of Metformin in Diabetes, Infections, Cognitive Dysfunction, and Cancer
por: Chow, Elaine, et al.
Publicado: (2022)

Metformin and the promise of geroprotection
por: Kalra, Sanjay, et al.
Publicado: (2012)

A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology
por: Upadhya, Dinesh, et al.
Publicado: (2019)

Age Related Prevalence of Mild Cognitive Impairment in Type 2 Diabetes Mellitus Patients in the Indian Population and Association of Serum Lipids With Cognitive Dysfunction
por: Chakraborty, Arpita, et al.
Publicado: (2021)

Effects of metformin on endothelial health and erectile dysfunction
por: Patel, Jay Pravin, et al.
Publicado: (2017)

Metformin prevents murine ovarian aging
por: Qin, Xian, et al.
Publicado: (2019)

Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
por: Chen, Sheng, et al.
Publicado: (2022)

Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
por: Auxtero, Maria D., et al.
Publicado: (2021)

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration
por: Upadhya, Dinesh, et al.
Publicado: (2019)

Postoperative cognitive dysfunction – current preventive strategies
por: Kotekar, Nalini, et al.
Publicado: (2018)

Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge
por: Wang, Ya, et al.
Publicado: (2022)

Is It Possible to Delay or Prevent Age-Related Cognitive Decline?
por: Michel, Jean-Pierre
Publicado: (2016)

An Epigenetic Hypothesis of Aging-Related Cognitive Dysfunction
por: Penner, Marsha R., et al.
Publicado: (2010)

Endothelial dysfunction in pathological processes of chronic liver disease during aging
por: Wan, Ying, et al.
Publicado: (2021)

The Interaction of Diet and Mitochondrial Dysfunction in Aging and Cognition
por: Kaliszewska, Aleksandra, et al.
Publicado: (2021)

Mastication as a tool to prevent cognitive dysfunctions()
por: Krishnamoorthy, Gayathri, et al.
Publicado: (2018)

The Relation between canine cognitive dysfunction and age-related brain lesions
por: OZAWA, Makiko, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_c6el8iqulnjucjdkoj8hk13lp1