Cargando…
Influence of Sox protein SUMOylation on neural development and regeneration
SRY-related HMG-box (Sox) transcription factors are known to regulate central nervous system development and are involved in several neurological diseases. Post-translational modification of Sox proteins is known to alter their functions in the central nervous system. Among the different types of po...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504373/ https://www.ncbi.nlm.nih.gov/pubmed/34380874 http://dx.doi.org/10.4103/1673-5374.320968 |
_version_ | 1784581309072408576 |
---|---|
author | Chang, Kun-Che |
author_facet | Chang, Kun-Che |
author_sort | Chang, Kun-Che |
collection | PubMed |
description | SRY-related HMG-box (Sox) transcription factors are known to regulate central nervous system development and are involved in several neurological diseases. Post-translational modification of Sox proteins is known to alter their functions in the central nervous system. Among the different types of post-translational modification, small ubiquitin-like modifier (SUMO) modification of Sox proteins has been shown to modify their transcriptional activity. Here, we review the mechanisms of three Sox proteins in neuronal development and disease, along with their transcriptional changes under SUMOylation. Across three species, lysine is the conserved residue for SUMOylation. In Drosophila, SUMOylation of SoxN plays a repressive role in transcriptional activity, which impairs central nervous system development. However, deSUMOylation of SoxE and Sox11 plays neuroprotective roles, which promote neural crest precursor formation in Xenopus and retinal ganglion cell differentiation as well as axon regeneration in the rodent. We further discuss a potential translational therapy by SUMO site modification using AAV gene transduction and Clustered regularly interspaced short palindromic repeats-Cas9 technology. Understanding the underlying mechanisms of Sox SUMOylation, especially in the rodent system, may provide a therapeutic strategy to address issues associated with neuronal development and neurodegeneration. |
format | Online Article Text |
id | pubmed-8504373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-85043732021-11-01 Influence of Sox protein SUMOylation on neural development and regeneration Chang, Kun-Che Neural Regen Res Review SRY-related HMG-box (Sox) transcription factors are known to regulate central nervous system development and are involved in several neurological diseases. Post-translational modification of Sox proteins is known to alter their functions in the central nervous system. Among the different types of post-translational modification, small ubiquitin-like modifier (SUMO) modification of Sox proteins has been shown to modify their transcriptional activity. Here, we review the mechanisms of three Sox proteins in neuronal development and disease, along with their transcriptional changes under SUMOylation. Across three species, lysine is the conserved residue for SUMOylation. In Drosophila, SUMOylation of SoxN plays a repressive role in transcriptional activity, which impairs central nervous system development. However, deSUMOylation of SoxE and Sox11 plays neuroprotective roles, which promote neural crest precursor formation in Xenopus and retinal ganglion cell differentiation as well as axon regeneration in the rodent. We further discuss a potential translational therapy by SUMO site modification using AAV gene transduction and Clustered regularly interspaced short palindromic repeats-Cas9 technology. Understanding the underlying mechanisms of Sox SUMOylation, especially in the rodent system, may provide a therapeutic strategy to address issues associated with neuronal development and neurodegeneration. Wolters Kluwer - Medknow 2021-08-04 /pmc/articles/PMC8504373/ /pubmed/34380874 http://dx.doi.org/10.4103/1673-5374.320968 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Chang, Kun-Che Influence of Sox protein SUMOylation on neural development and regeneration |
title | Influence of Sox protein SUMOylation on neural development and regeneration |
title_full | Influence of Sox protein SUMOylation on neural development and regeneration |
title_fullStr | Influence of Sox protein SUMOylation on neural development and regeneration |
title_full_unstemmed | Influence of Sox protein SUMOylation on neural development and regeneration |
title_short | Influence of Sox protein SUMOylation on neural development and regeneration |
title_sort | influence of sox protein sumoylation on neural development and regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504373/ https://www.ncbi.nlm.nih.gov/pubmed/34380874 http://dx.doi.org/10.4103/1673-5374.320968 |
work_keys_str_mv | AT changkunche influenceofsoxproteinsumoylationonneuraldevelopmentandregeneration |