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CGRP release in an experimental human trigeminal pain model
BACKGROUND: Migraine and trigemino-autonomic cephalalgia attacks are associated with an increase of α-calcitonin-gene related peptide levels in the ipsilateral jugular vein. It is however unknown whether trigeminal pain stimulation in healthy subjects without headache disorders also induces increase...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504405/ https://www.ncbi.nlm.nih.gov/pubmed/34148405 http://dx.doi.org/10.1177/03331024211017250 |
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author | Frese, Achim Summ, Oliver Evers, Stefan |
author_facet | Frese, Achim Summ, Oliver Evers, Stefan |
author_sort | Frese, Achim |
collection | PubMed |
description | BACKGROUND: Migraine and trigemino-autonomic cephalalgia attacks are associated with an increase of α-calcitonin-gene related peptide levels in the ipsilateral jugular vein. It is however unknown whether trigeminal pain stimulation in healthy subjects without headache disorders also induces increase of calcitonin-gene related peptide levels. FINDINGS: We measured α-calcitonin-gene related peptide levels in eight healthy subjects after subcutaneous injection of capsaicin in the forehead and in the mandibular region and after injection of sodium chloride in the forehead. We observed a significant increase of α-calcitonin-gene related peptide level only after injection of capsaicin in the forehead (i.e. first trigeminal branch). We also observed trigemino-autonomic activation (lacrimation, rhinorrhea etc.) only after injection of capsaicin in the forehead. CONCLUSION: Increase of α-calcitonin-gene related peptide levels do not only occur in primary headache attacks but also after experimental trigeminal pain of the first branch. This finding suggests that α-calcitonin-gene related peptide elevation is, at least an additional, unspecific effect of first trigeminal branch stimulation following pain activation and not a specific mechanism of idiopathic headache disorders. |
format | Online Article Text |
id | pubmed-8504405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-85044052021-10-12 CGRP release in an experimental human trigeminal pain model Frese, Achim Summ, Oliver Evers, Stefan Cephalalgia Brief Reports BACKGROUND: Migraine and trigemino-autonomic cephalalgia attacks are associated with an increase of α-calcitonin-gene related peptide levels in the ipsilateral jugular vein. It is however unknown whether trigeminal pain stimulation in healthy subjects without headache disorders also induces increase of calcitonin-gene related peptide levels. FINDINGS: We measured α-calcitonin-gene related peptide levels in eight healthy subjects after subcutaneous injection of capsaicin in the forehead and in the mandibular region and after injection of sodium chloride in the forehead. We observed a significant increase of α-calcitonin-gene related peptide level only after injection of capsaicin in the forehead (i.e. first trigeminal branch). We also observed trigemino-autonomic activation (lacrimation, rhinorrhea etc.) only after injection of capsaicin in the forehead. CONCLUSION: Increase of α-calcitonin-gene related peptide levels do not only occur in primary headache attacks but also after experimental trigeminal pain of the first branch. This finding suggests that α-calcitonin-gene related peptide elevation is, at least an additional, unspecific effect of first trigeminal branch stimulation following pain activation and not a specific mechanism of idiopathic headache disorders. SAGE Publications 2021-06-20 2021-10 /pmc/articles/PMC8504405/ /pubmed/34148405 http://dx.doi.org/10.1177/03331024211017250 Text en © International Headache Society 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Brief Reports Frese, Achim Summ, Oliver Evers, Stefan CGRP release in an experimental human trigeminal pain model |
title | CGRP release in an experimental human trigeminal pain model |
title_full | CGRP release in an experimental human trigeminal pain model |
title_fullStr | CGRP release in an experimental human trigeminal pain model |
title_full_unstemmed | CGRP release in an experimental human trigeminal pain model |
title_short | CGRP release in an experimental human trigeminal pain model |
title_sort | cgrp release in an experimental human trigeminal pain model |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504405/ https://www.ncbi.nlm.nih.gov/pubmed/34148405 http://dx.doi.org/10.1177/03331024211017250 |
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