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CGRP release in an experimental human trigeminal pain model

BACKGROUND: Migraine and trigemino-autonomic cephalalgia attacks are associated with an increase of α-calcitonin-gene related peptide levels in the ipsilateral jugular vein. It is however unknown whether trigeminal pain stimulation in healthy subjects without headache disorders also induces increase...

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Autores principales: Frese, Achim, Summ, Oliver, Evers, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504405/
https://www.ncbi.nlm.nih.gov/pubmed/34148405
http://dx.doi.org/10.1177/03331024211017250
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author Frese, Achim
Summ, Oliver
Evers, Stefan
author_facet Frese, Achim
Summ, Oliver
Evers, Stefan
author_sort Frese, Achim
collection PubMed
description BACKGROUND: Migraine and trigemino-autonomic cephalalgia attacks are associated with an increase of α-calcitonin-gene related peptide levels in the ipsilateral jugular vein. It is however unknown whether trigeminal pain stimulation in healthy subjects without headache disorders also induces increase of calcitonin-gene related peptide levels. FINDINGS: We measured α-calcitonin-gene related peptide levels in eight healthy subjects after subcutaneous injection of capsaicin in the forehead and in the mandibular region and after injection of sodium chloride in the forehead. We observed a significant increase of α-calcitonin-gene related peptide level only after injection of capsaicin in the forehead (i.e. first trigeminal branch). We also observed trigemino-autonomic activation (lacrimation, rhinorrhea etc.) only after injection of capsaicin in the forehead. CONCLUSION: Increase of α-calcitonin-gene related peptide levels do not only occur in primary headache attacks but also after experimental trigeminal pain of the first branch. This finding suggests that α-calcitonin-gene related peptide elevation is, at least an additional, unspecific effect of first trigeminal branch stimulation following pain activation and not a specific mechanism of idiopathic headache disorders.
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spelling pubmed-85044052021-10-12 CGRP release in an experimental human trigeminal pain model Frese, Achim Summ, Oliver Evers, Stefan Cephalalgia Brief Reports BACKGROUND: Migraine and trigemino-autonomic cephalalgia attacks are associated with an increase of α-calcitonin-gene related peptide levels in the ipsilateral jugular vein. It is however unknown whether trigeminal pain stimulation in healthy subjects without headache disorders also induces increase of calcitonin-gene related peptide levels. FINDINGS: We measured α-calcitonin-gene related peptide levels in eight healthy subjects after subcutaneous injection of capsaicin in the forehead and in the mandibular region and after injection of sodium chloride in the forehead. We observed a significant increase of α-calcitonin-gene related peptide level only after injection of capsaicin in the forehead (i.e. first trigeminal branch). We also observed trigemino-autonomic activation (lacrimation, rhinorrhea etc.) only after injection of capsaicin in the forehead. CONCLUSION: Increase of α-calcitonin-gene related peptide levels do not only occur in primary headache attacks but also after experimental trigeminal pain of the first branch. This finding suggests that α-calcitonin-gene related peptide elevation is, at least an additional, unspecific effect of first trigeminal branch stimulation following pain activation and not a specific mechanism of idiopathic headache disorders. SAGE Publications 2021-06-20 2021-10 /pmc/articles/PMC8504405/ /pubmed/34148405 http://dx.doi.org/10.1177/03331024211017250 Text en © International Headache Society 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Brief Reports
Frese, Achim
Summ, Oliver
Evers, Stefan
CGRP release in an experimental human trigeminal pain model
title CGRP release in an experimental human trigeminal pain model
title_full CGRP release in an experimental human trigeminal pain model
title_fullStr CGRP release in an experimental human trigeminal pain model
title_full_unstemmed CGRP release in an experimental human trigeminal pain model
title_short CGRP release in an experimental human trigeminal pain model
title_sort cgrp release in an experimental human trigeminal pain model
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504405/
https://www.ncbi.nlm.nih.gov/pubmed/34148405
http://dx.doi.org/10.1177/03331024211017250
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