Cargando…

Large‐scale whole‐exome sequencing association study identifies FOXH1 gene and sphingolipid metabolism pathway influencing major depressive disorder

In the present study, we performed an exome‐wide investigation of the burden of rare disease‐causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene‐based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant ass...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Wei, Chen, Luan, Jiang, Bixuan, Sun, Yidan, Li, Mo, Wu, Hao, Zhang, Na, Sun, Xiaofang, Qin, Shengying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Letter to the Editor
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504519/ https://www.ncbi.nlm.nih.gov/pubmed/34633764 http://dx.doi.org/10.1111/cns.13733

Ejemplares similares

Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients
por: Li, Mo, et al.
Publicado: (2020)

How mutant p53 empowers Foxh1 fostering leukaemogenesis?
por: Amelio, Ivano
Publicado: (2019)

FOXH1 Is Regulated by NANOG and LIN28 for Early-stage Reprogramming
por: Wang, Ling, et al.
Publicado: (2019)

High-Coverage Whole-Exome Sequencing Identifies Candidate Genes for Suicide in Victims with Major Depressive Disorder
por: Tombácz, Dóra, et al.
Publicado: (2017)

Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin
por: Slagle, Christopher E., et al.
Publicado: (2011)

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1
por: Pluta, Radoslaw, et al.
Publicado: (2022)

A latent genetic subtype of major depression identified by whole-exome genotyping data in a Mexican-American cohort
por: Yu, C, et al.
Publicado: (2017)

FOXH1 promotes lung cancer progression by activating the Wnt/β-catenin signaling pathway
por: Zhang, Jun, et al.
Publicado: (2021)

Clinical Application of Whole Exome Sequencing to Identify Rare but Remediable Neurologic Disorders
por: Kim, Min-Jee, et al.
Publicado: (2020)

A comprehensive analysis of FOX family in HCC and experimental evidence to support the oncogenic role of FOXH1
por: Ouyang, Xiwu, et al.
Publicado: (2022)

Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer
por: Xu, Jingxiong, et al.
Publicado: (2023)

Whole-exome sequencing data of suicide victims who had suffered from major depressive disorder
por: Tombácz, Dóra, et al.
Publicado: (2019)

Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels
por: Tin, Adrienne, et al.
Publicado: (2018)

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
por: Aragón, Eric, et al.
Publicado: (2019)

FoxH1 Represses the Promoter Activity of cyp19a1a in the Ricefield Eel (Monopterus albus)
por: He, Zhi, et al.
Publicado: (2023)

Developmentally Regulated Sphingolipid Degradation in Leishmania major
por: Zhang, Ou, et al.
Publicado: (2012)

A large‐scale whole‐exome sequencing mutant resource for functional genomics in wheat
por: Xiong, Hongchun, et al.
Publicado: (2023)

FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation
por: Fischer, Patrick, et al.
Publicado: (2019)

Foxh1/Nodal Defines Context-Specific Direct Maternal Wnt/β-Catenin Target Gene Regulation in Early Development
por: Afouda, Boni A., et al.
Publicado: (2020)

Different responses to risperidone treatment in Schizophrenia: a multicenter genome-wide association and whole exome sequencing joint study
por: Zhao, Mingzhe, et al.
Publicado: (2022)

Whole-exome sequencing identifies variants in invasive pituitary adenomas
por: Lan, Xiaolei, et al.
Publicado: (2016)

Whole-exome analysis in osteosarcoma to identify a personalized therapy
por: Chiappetta, Caterina, et al.
Publicado: (2017)

Whole exome sequencing identifies mutational signatures of vitreoretinal lymphoma
por: Lee, Junwon, et al.
Publicado: (2020)

Mendelian etiologies identified with whole exome sequencing in cerebral palsy
por: Chopra, Maya, et al.
Publicado: (2022)

Whole Exome Sequencing Identifies a Novel Pathogenic RET Variant in Hirschsprung Disease
por: Wu, Wei, et al.
Publicado: (2019)

Whole exome sequencing identifies causative mutations in the majority of consanguineous or familial cases with childhood-onset increased renal echogenicity
por: Braun, Daniela A., et al.
Publicado: (2016)

Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis
por: Zuo, Xianbo, et al.
Publicado: (2015)

Whole-exome sequencing analysis identifies novel variants associated with Kawasaki disease susceptibility
por: Zhang, Xing, et al.
Publicado: (2023)

Novel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing
por: Wu, Song, et al.
Publicado: (2015)

Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease
por: Song, Jae-Hwi, et al.
Publicado: (2021)

Unraveling the genetic causes in large pedigrees with gout by whole-exome sequencing
por: Xia, Xiaoru, et al.
Publicado: (2020)

Whole-Exome Sequencing Identifies a Novel CPT2 Mutation in a Pedigree With Gout
por: Guo, Yong, et al.
Publicado: (2022)

Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene
por: Dicks, Ed, et al.
Publicado: (2017)

Novel pathogenic variants and genes for myopathies identified by whole exome sequencing
por: Hunter, Jesse M, et al.
Publicado: (2015)

Whole exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas
por: Fishbein, Lauren, et al.
Publicado: (2015)

Whole exome sequencing to identify genetic markers for trastuzumab‐induced cardiotoxicity
por: Udagawa, Chihiro, et al.
Publicado: (2018)

Common Variable Immunodeficiency with Genetic Defects Identified by Whole Exome Sequencing
por: Li, Ran, et al.
Publicado: (2018)

Whole Exome Sequencing Identifies Atypical Welander Distal Myopathy in Patient
por: Gass, Jennifer, et al.
Publicado: (2017)

Whole-Exome Sequencing for Identifying Genetic Causes of Intellectual Developmental Disorders
por: Guo, Yu-Xiong, et al.
Publicado: (2021)

Pathogenic variants identified by whole-exome sequencing in 43 patients with epilepsy
por: Zhang, Linlin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_i716f9k5gui2dkp2dpe16ugub0