Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in aged mice

AIMS: Delayed neurocognitive recovery (dNCR) is a common postoperative complication in geriatric surgical patients for which there is no efficacious therapy. Cholecystokinin octapeptide (CCK‐8), an immunomodulatory peptide, regulates memory and learning. Here, we explored the effects and mechanism o...

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Detalles Bibliográficos
Autores principales: Chen, Lei, Yang, Ning, Li, Yue, Li, Yitong, Hong, Jingshu, Wang, Qian, Liu, Kaixi, Han, Dengyang, Han, Yongzheng, Mi, Xinning, Shi, Chengmei, Zhou, Ying, Li, Zhengqian, Liu, Taotao, Guo, Xiangyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504528/
https://www.ncbi.nlm.nih.gov/pubmed/34402181
http://dx.doi.org/10.1111/cns.13718

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