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Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated phenomenon characterized by demyelination of the central nervous system that displays numerous manifestations. It predominantly presents in children with a mean age range of five to eight years. ADEM remains a diagnosis of exclusion b...

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Autores principales: AlZeera, Abdulla J, Alkhaja, Aysha, Noor, Dana H, Alsaffar, Sayed Mohamed R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504557/
https://www.ncbi.nlm.nih.gov/pubmed/34659929
http://dx.doi.org/10.7759/cureus.18669
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author AlZeera, Abdulla J
Alkhaja, Aysha
Noor, Dana H
Alsaffar, Sayed Mohamed R
author_facet AlZeera, Abdulla J
Alkhaja, Aysha
Noor, Dana H
Alsaffar, Sayed Mohamed R
author_sort AlZeera, Abdulla J
collection PubMed
description Acute disseminated encephalomyelitis (ADEM) is an immune-mediated phenomenon characterized by demyelination of the central nervous system that displays numerous manifestations. It predominantly presents in children with a mean age range of five to eight years. ADEM remains a diagnosis of exclusion based on clinical and radiographic progression. Thus, it poses a diagnostic challenge. ADEM has been shown to be very responsive to steroids and exchange therapy. Here, we present an unusual case of ADEM in a 50-year-old female patient who, despite receiving an entire course of IV methylprednisolone and other conventional treatment methods, did not respond to the treatment.
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spelling pubmed-85045572021-10-15 Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids AlZeera, Abdulla J Alkhaja, Aysha Noor, Dana H Alsaffar, Sayed Mohamed R Cureus Internal Medicine Acute disseminated encephalomyelitis (ADEM) is an immune-mediated phenomenon characterized by demyelination of the central nervous system that displays numerous manifestations. It predominantly presents in children with a mean age range of five to eight years. ADEM remains a diagnosis of exclusion based on clinical and radiographic progression. Thus, it poses a diagnostic challenge. ADEM has been shown to be very responsive to steroids and exchange therapy. Here, we present an unusual case of ADEM in a 50-year-old female patient who, despite receiving an entire course of IV methylprednisolone and other conventional treatment methods, did not respond to the treatment. Cureus 2021-10-11 /pmc/articles/PMC8504557/ /pubmed/34659929 http://dx.doi.org/10.7759/cureus.18669 Text en Copyright © 2021, AlZeera et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
AlZeera, Abdulla J
Alkhaja, Aysha
Noor, Dana H
Alsaffar, Sayed Mohamed R
Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids
title Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids
title_full Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids
title_fullStr Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids
title_full_unstemmed Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids
title_short Adult-Onset Acute Disseminated Encephalomyelitis Refractory to Steroids
title_sort adult-onset acute disseminated encephalomyelitis refractory to steroids
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504557/
https://www.ncbi.nlm.nih.gov/pubmed/34659929
http://dx.doi.org/10.7759/cureus.18669
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