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Planning and delivery of intensity modulated bolus electron conformal therapy

PURPOSE: Bolus electron conformal therapy (BECT) is a clinically useful, well‐documented, and available technology. The addition of intensity modulation (IM) to BECT reduces volumes of high dose and dose spread in the planning target volume (PTV). This paper demonstrates new techniques for a process...

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Autores principales: Hilliard, Elizabeth N., Carver, Robert L., Chambers, Erin L., Kavanaugh, James A., Erhart, Kevin J., McGuffey, Andrew S., Hogstrom, Kenneth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504596/
https://www.ncbi.nlm.nih.gov/pubmed/34558774
http://dx.doi.org/10.1002/acm2.13386
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author Hilliard, Elizabeth N.
Carver, Robert L.
Chambers, Erin L.
Kavanaugh, James A.
Erhart, Kevin J.
McGuffey, Andrew S.
Hogstrom, Kenneth R.
author_facet Hilliard, Elizabeth N.
Carver, Robert L.
Chambers, Erin L.
Kavanaugh, James A.
Erhart, Kevin J.
McGuffey, Andrew S.
Hogstrom, Kenneth R.
author_sort Hilliard, Elizabeth N.
collection PubMed
description PURPOSE: Bolus electron conformal therapy (BECT) is a clinically useful, well‐documented, and available technology. The addition of intensity modulation (IM) to BECT reduces volumes of high dose and dose spread in the planning target volume (PTV). This paper demonstrates new techniques for a process that should be suitable for planning and delivering IM‐BECT using passive radiotherapy intensity modulation for electrons (PRIME) devices. METHODS: The IM‐BECT planning and delivery process is an addition to the BECT process that includes intensity modulator design, fabrication, and quality assurance. The intensity modulator (PRIME device) is a hexagonal matrix of small island blocks (tungsten pins of varying diameter) placed inside the patient beam‐defining collimator (cutout). Its design process determines a desirable intensity‐modulated electron beam during the planning process, then determines the island block configuration to deliver that intensity distribution (segmentation). The intensity modulator is fabricated and quality assurance performed at the factory (.decimal, LLC, Sanford, FL). Clinical quality assurance consists of measuring a fluence distribution in a plane perpendicular to the beam in a water or water‐equivalent phantom. This IM‐BECT process is described and demonstrated for two sites, postmastectomy chest wall and temple. Dose plans, intensity distributions, fabricated intensity modulators, and quality assurance results are presented. RESULTS: IM‐BECT plans showed improved D(90‐10) over BECT plans, 6.4% versus 7.3% and 8.4% versus 11.0% for the postmastectomy chest wall and temple, respectively. Their intensity modulators utilized 61 (single diameter) and 246 (five diameters) tungsten pins, respectively. Dose comparisons for clinical quality assurance showed that for doses greater than 10%, measured agreed with calculated dose within 3% or 0.3 cm distance‐to‐agreement (DTA) for 99.9% and 100% of points, respectively. CONCLUSION: These results demonstrated the feasibility of translating IM‐BECT to the clinic using the techniques presented for treatment planning, intensity modulator design and fabrication, and quality assurance processes.
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spelling pubmed-85045962021-10-18 Planning and delivery of intensity modulated bolus electron conformal therapy Hilliard, Elizabeth N. Carver, Robert L. Chambers, Erin L. Kavanaugh, James A. Erhart, Kevin J. McGuffey, Andrew S. Hogstrom, Kenneth R. J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: Bolus electron conformal therapy (BECT) is a clinically useful, well‐documented, and available technology. The addition of intensity modulation (IM) to BECT reduces volumes of high dose and dose spread in the planning target volume (PTV). This paper demonstrates new techniques for a process that should be suitable for planning and delivering IM‐BECT using passive radiotherapy intensity modulation for electrons (PRIME) devices. METHODS: The IM‐BECT planning and delivery process is an addition to the BECT process that includes intensity modulator design, fabrication, and quality assurance. The intensity modulator (PRIME device) is a hexagonal matrix of small island blocks (tungsten pins of varying diameter) placed inside the patient beam‐defining collimator (cutout). Its design process determines a desirable intensity‐modulated electron beam during the planning process, then determines the island block configuration to deliver that intensity distribution (segmentation). The intensity modulator is fabricated and quality assurance performed at the factory (.decimal, LLC, Sanford, FL). Clinical quality assurance consists of measuring a fluence distribution in a plane perpendicular to the beam in a water or water‐equivalent phantom. This IM‐BECT process is described and demonstrated for two sites, postmastectomy chest wall and temple. Dose plans, intensity distributions, fabricated intensity modulators, and quality assurance results are presented. RESULTS: IM‐BECT plans showed improved D(90‐10) over BECT plans, 6.4% versus 7.3% and 8.4% versus 11.0% for the postmastectomy chest wall and temple, respectively. Their intensity modulators utilized 61 (single diameter) and 246 (five diameters) tungsten pins, respectively. Dose comparisons for clinical quality assurance showed that for doses greater than 10%, measured agreed with calculated dose within 3% or 0.3 cm distance‐to‐agreement (DTA) for 99.9% and 100% of points, respectively. CONCLUSION: These results demonstrated the feasibility of translating IM‐BECT to the clinic using the techniques presented for treatment planning, intensity modulator design and fabrication, and quality assurance processes. John Wiley and Sons Inc. 2021-09-24 /pmc/articles/PMC8504596/ /pubmed/34558774 http://dx.doi.org/10.1002/acm2.13386 Text en © 2021 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Hilliard, Elizabeth N.
Carver, Robert L.
Chambers, Erin L.
Kavanaugh, James A.
Erhart, Kevin J.
McGuffey, Andrew S.
Hogstrom, Kenneth R.
Planning and delivery of intensity modulated bolus electron conformal therapy
title Planning and delivery of intensity modulated bolus electron conformal therapy
title_full Planning and delivery of intensity modulated bolus electron conformal therapy
title_fullStr Planning and delivery of intensity modulated bolus electron conformal therapy
title_full_unstemmed Planning and delivery of intensity modulated bolus electron conformal therapy
title_short Planning and delivery of intensity modulated bolus electron conformal therapy
title_sort planning and delivery of intensity modulated bolus electron conformal therapy
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504596/
https://www.ncbi.nlm.nih.gov/pubmed/34558774
http://dx.doi.org/10.1002/acm2.13386
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