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Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility

To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (desi...

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Autores principales: Mayerhofer, Michael, Bergmaier, Andreas, Datzmann, Gerd, Hagn, Hermann, Helm, Ricardo, Mitteneder, Johannes, Schubert, Ralf, Picardi, Luigi, Nenzi, Paolo, Ronsivalle, Concetta, Wirth, Hans-Friedrich, Dollinger, Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504737/
https://www.ncbi.nlm.nih.gov/pubmed/34634079
http://dx.doi.org/10.1371/journal.pone.0258477
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author Mayerhofer, Michael
Bergmaier, Andreas
Datzmann, Gerd
Hagn, Hermann
Helm, Ricardo
Mitteneder, Johannes
Schubert, Ralf
Picardi, Luigi
Nenzi, Paolo
Ronsivalle, Concetta
Wirth, Hans-Friedrich
Dollinger, Günther
author_facet Mayerhofer, Michael
Bergmaier, Andreas
Datzmann, Gerd
Hagn, Hermann
Helm, Ricardo
Mitteneder, Johannes
Schubert, Ralf
Picardi, Luigi
Nenzi, Paolo
Ronsivalle, Concetta
Wirth, Hans-Friedrich
Dollinger, Günther
author_sort Mayerhofer, Michael
collection PubMed
description To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W.
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spelling pubmed-85047372021-10-12 Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility Mayerhofer, Michael Bergmaier, Andreas Datzmann, Gerd Hagn, Hermann Helm, Ricardo Mitteneder, Johannes Schubert, Ralf Picardi, Luigi Nenzi, Paolo Ronsivalle, Concetta Wirth, Hans-Friedrich Dollinger, Günther PLoS One Research Article To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W. Public Library of Science 2021-10-11 /pmc/articles/PMC8504737/ /pubmed/34634079 http://dx.doi.org/10.1371/journal.pone.0258477 Text en © 2021 Mayerhofer et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mayerhofer, Michael
Bergmaier, Andreas
Datzmann, Gerd
Hagn, Hermann
Helm, Ricardo
Mitteneder, Johannes
Schubert, Ralf
Picardi, Luigi
Nenzi, Paolo
Ronsivalle, Concetta
Wirth, Hans-Friedrich
Dollinger, Günther
Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility
title Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility
title_full Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility
title_fullStr Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility
title_full_unstemmed Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility
title_short Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility
title_sort concept and performance evaluation of two 3 ghz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504737/
https://www.ncbi.nlm.nih.gov/pubmed/34634079
http://dx.doi.org/10.1371/journal.pone.0258477
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