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Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility
To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (desi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504737/ https://www.ncbi.nlm.nih.gov/pubmed/34634079 http://dx.doi.org/10.1371/journal.pone.0258477 |
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author | Mayerhofer, Michael Bergmaier, Andreas Datzmann, Gerd Hagn, Hermann Helm, Ricardo Mitteneder, Johannes Schubert, Ralf Picardi, Luigi Nenzi, Paolo Ronsivalle, Concetta Wirth, Hans-Friedrich Dollinger, Günther |
author_facet | Mayerhofer, Michael Bergmaier, Andreas Datzmann, Gerd Hagn, Hermann Helm, Ricardo Mitteneder, Johannes Schubert, Ralf Picardi, Luigi Nenzi, Paolo Ronsivalle, Concetta Wirth, Hans-Friedrich Dollinger, Günther |
author_sort | Mayerhofer, Michael |
collection | PubMed |
description | To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W. |
format | Online Article Text |
id | pubmed-8504737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-85047372021-10-12 Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility Mayerhofer, Michael Bergmaier, Andreas Datzmann, Gerd Hagn, Hermann Helm, Ricardo Mitteneder, Johannes Schubert, Ralf Picardi, Luigi Nenzi, Paolo Ronsivalle, Concetta Wirth, Hans-Friedrich Dollinger, Günther PLoS One Research Article To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W. Public Library of Science 2021-10-11 /pmc/articles/PMC8504737/ /pubmed/34634079 http://dx.doi.org/10.1371/journal.pone.0258477 Text en © 2021 Mayerhofer et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mayerhofer, Michael Bergmaier, Andreas Datzmann, Gerd Hagn, Hermann Helm, Ricardo Mitteneder, Johannes Schubert, Ralf Picardi, Luigi Nenzi, Paolo Ronsivalle, Concetta Wirth, Hans-Friedrich Dollinger, Günther Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility |
title | Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility |
title_full | Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility |
title_fullStr | Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility |
title_full_unstemmed | Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility |
title_short | Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility |
title_sort | concept and performance evaluation of two 3 ghz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504737/ https://www.ncbi.nlm.nih.gov/pubmed/34634079 http://dx.doi.org/10.1371/journal.pone.0258477 |
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