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SMAD4 loss is associated with response to neoadjuvant chemotherapy plus hydroxychloroquine in patients with pancreatic adenocarcinoma

SMAD4, a tumor suppressor gene, is lost in up to 60%–90% of pancreatic adenocarcinomas (PDAs). Loss of SMAD4 allows tumor progression by upregulating autophagy, a cell survival mechanism that counteracts apoptosis and allows intracellular recycling of macromolecules. Hydroxychloroquine (HCQ) is an a...

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Detalles Bibliográficos
Autores principales:	Fei, Naomi, Wen, Sijin, Ramanathan, Rajesh, Hogg, Melissa E., Zureikat, Amer H., Lotze, Michael T., Bahary, Nathan, Singhi, Aatur D., Zeh, Herbert J., Boone, Brian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504806/ https://www.ncbi.nlm.nih.gov/pubmed/34002944 http://dx.doi.org/10.1111/cts.13029

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