Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys

The impact of organic anion‐transporting polypeptide (OATP) inhibition on systemic and liver exposures of three OATP substrates was investigated in cynomolgus monkeys. A monkey physiologically‐based pharmacokinetic (PBPK) model was constructed to describe the exposure changes followed by OATP functi...

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Detalles Bibliográficos
Autores principales: Cheng, Yaofeng, Liang, Xiaomin, Hao, Jia, Niu, Congrong, Lai, Yurong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504809/
https://www.ncbi.nlm.nih.gov/pubmed/34058067
http://dx.doi.org/10.1111/cts.13047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504809/
https://www.ncbi.nlm.nih.gov/pubmed/34058067
http://dx.doi.org/10.1111/cts.13047

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